摘要
泛醌－细胞色素ｃ还原酶（ＱＣＲ）是线粒体呼吸链的三个能量偶联部位之一，它起着将电子从还原型泛醌传递给细胞色素ｃ（Ｃｙｔ．ｃ）的作用，根据Ｋｉｎｇ和Ｙｕ提出的泛醌结合蛋白理论［１］，泛醌－细胞色素ｃ还原酶中含有泛醌结合蛋白ＱＰｃ．研究表明，泛醌－细胞色...
The inhibitory effect of 3 and 5 nirtosalicyl N methylamide on the activity of ubiquinol cytochrome c reductase was studied.As a result,their inhibiton was not sensitive to the substrate of different ubiquinols used.There was no obvious difference among the inhibitory effects of 3 and 5 nitrosalicyl N methylamide on the activity of ubiquinol cytochrome c reductase,while Q 2H 2,DQH 2 and Q 0c 10 H 2 acted as substrate for providing electrons,which demonstrated that the substrated group on quinone affected little to the two inhibitors exhibiting their inhibition to QCR,and it could be ascribed to their effects of disturbing the reaction of hydration and dehydration of quinone.The results by comparing the inhibition of 3 and 5 nitrosalicyl N methylamide on ubiquinol cytochrome c reductase showed that there was no relationship between the inhibitory effects and the position of the substrated nitro group.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
1999年第2期337-339,共3页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金
关键词
硝基水杨酰胺
泛醌
细胞色素C
还原酶
氢醌
Nitrosalicyl N methylamide
5 Nitrosalicyl N methylamide
Respiratory chain
Ubiquinone
Ubiquinol cytochrome c reductase
