摘要
蚊虫是多种人类传染疾病的主要传播媒介，如疟疾、丝虫病、乙型脑炎、黄热病和登革热等，对人类的健康造成了极大的危害［１］。控制蚊虫被认为是消除这些蚊媒疾病的有效途径。在过去的４５年里，尽管化学杀虫剂和各种抗病药物的使用对降低疟疾和蚊媒疾病的发病率和死亡率...
Abstract Bacillus sphaericus is an ubiquitous, cosmopolitan, aerobic, spore forming bacteria. Nine serotype strains among them are pathogenic for mosquito larvae. The most active strains produce a crystal toxin which is composed of two proteins of 51 4 and 41 9kD during sporulation. After larvae ingest the spore/crystal complex, the crystal toxin is hydrolyzed into active toxins and bind to a specific receptor on midgut brush border membranes. The resulting damage of the midgut cells leads to the death of mosquitoes. During the vegetative growth, the low toxic and some high toxic strains synthesize mosquito larvicidal proteins of 100, 31 5 and 35 8kD(Mtx toxins). It is proved that these toxins have no homology with the crystal toxin and other insecticidal toxins. For better control of mosquito larvae, cloning and expressing of the crystal and Mtx toxin genes in different hosts have been studied. In this paper, the recent progress and development on mosquito larvicidal toxins of B.sphaericus and their genetic manipulation for mosquito control are reviewed.
出处
《昆虫学报》
CAS
CSCD
北大核心
1999年第2期212-224,共13页
Acta Entomologica Sinica
