期刊文献+

老年多器官衰竭首发器官及序贯分析

Analysis of the first failure organ and sequential failure on mutiple organ failure in the elderly
原文传递
导出
摘要 目的 随访研究老年多器官衰竭(MOFE)首发器官及序贯发生规律,为临床早期诊断和治疗及二级、三级预防提供科学依据.方法 回顾性分析发生MOFE 153例患者的临床资料,用1:3配比病例对照随访研究方法进行分析.结果 153例MOFE患者发生诱因以感染为首位占89.5%(137/153),其中肺部感染占93.4%(128/137).纵向百分比首衰器官为肺(39.0%,60/154),其次为心(19.5%,30/154)、中枢(14.9%,23/154)、肾(10.4%,16/154)、胃肠(8.4%,13/154)、肝(6.5%,10/154)等;横向百分比首衰器官为肺(42.9%,60/140)、心(40.9%,56/137)、肾(32.6%,30/92)、中枢(21.9%,23/105)、胃肠(14.5%,9/62)等.首衰器官由短到长生存时间分别为肺、中枢、心、肾.结论 MOFE多为肺首衰.器官序贯衰竭顺序为肺、心、脑、肾等. Objective To provide a scientific basis for early clinical diagnosis and treatment as well as secondary and tertiary protection through 10 years inquiry of multiple organ failure in the elderly(MOFE).Results Among 153 MOFE cases,the first inducement of 89.5%(137/153) patients was infection,among which 93.4% (128/137) was pulmonary infection.The vertical percentage of the first failure organ was as follows: pulmonary (39.0%,60/154),heart (19.5%,30/154),brain (14.9%,23/154),kidney (10.4%,16/154),alimentary canal (8.4%,13/154),liver (6.5%,10/154);while the horizontal percentage was as follows: pulmonary (42.9%,60/140),heart (40.9%,56/137),kidney (32.6%,30/92),brain (21.9%,23/105),alimentary canal ( 14.5%,9/62).The survival time of the first organ failure from shortness to length was as follows: pulmonary,brain,heart,kidney.Conclusions Most MOFE cases have pulmonary failure at first.The organs failure sequence is pulmonary,heart,brain and kidney in order.
出处 《中国医师进修杂志》 2010年第28期17-20,共4页 Chinese Journal of Postgraduates of Medicine
关键词 多器官功能衰竭 老年人 序贯衰竭 生存时间 Multiple organ failure Aged Sequential failure Survival time
  • 相关文献

参考文献6

二级参考文献35

  • 1钱小顺,侯允天,薛桥,韩亚玲,刘雪红,刘建立,王士雯.1605例老年多器官功能衰竭的临床分析[J].中华老年多器官疾病杂志,2002,1(1):7-10. 被引量:126
  • 2朱庆磊,杨,钱小顺,尹彤,薛桥,徐斌,王士雯.老龄大鼠非细菌性多器官功能不全综合征模型的建立[J].中华老年多器官疾病杂志,2004,3(3):200-204. 被引量:7
  • 3[1]Smalls NM.The multiorgan system failure syndrome and adult respiratory distress in critically ill surgical patients.Hosp Phys,1992,28:43-47.
  • 4[6]Zhu QL,Qian XS,Wang SW,et al.A comparison of elderly and adult multiple organ dysfunction syndrome in the rat model.Exp Gerontol,2006,41:771-777.
  • 5[8]Baue AE,Durham R,Faist E.Systemic inflammatory response syndrome(SIRS),multiple organ dysfunction syndrome(MODS),multiple organ failure (MOF):are we winning the battle?Shock,1998,10:79-89.
  • 6[9]Tsutsumi-Ishii Y,Nagaoka I.Modulation of humandefensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production.J Immunol,2003,170:4226-4236.
  • 7[10]Monick MM,Yarovinsky TO,Powers L,et al.Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin.J Biol Chem,2003,278:53035-53044.
  • 8[11]Farberman MM,Hoffmann JW,Ryerse JS,et al.Diffusible signal to murine alveolar maerophages from coli-stimulated lung type Ⅱ epithelial cells.Inflamm Res,2004,53:475-483.
  • 9[12]Tao F,Kobzik L.Lung macropage-epithelial cell interaetions amplify particle-mediated cytokine release.Am J Respir Cell Mol Biol,2002,26:499-505.
  • 10[13]Thorley AJ,Coldstraw P,Young A,et al.Primary human alveolar type Ⅱ epithelial cell CCL20(macrophage inflammatory protein-3)-induced dentritic cell migration.Am J Respir Cell Mol Biol,2005,32:262-267.

共引文献1731

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部