摘要
目的：为明确鼻腔鼻窦鳞癌、癌前期病变与癌基因ｃ－ｍｙｃ的关系，为鼻腔鼻窦鳞癌和癌前期病变的早期诊断和诊疗提供依据和方法。方法：利用分子生物学技术对４４例标本进行分子病因学研究，包括２４例鼻腔鼻窦鳞癌，１５例良性肿瘤和５例鼻腔正常组织。结果：２４例鼻腔鼻窦鳞癌ｃ－ｍｙｃ的扩增倍数为１０～４０倍，癌前期病变组ｃ－ｍｙｃ的扩增倍数为５～１０倍，良性肿瘤及鼻腔正常组织中ｃ－ｍｙｃ的扩增倍数为５倍以下。结论：ｃ－ｍｙｃ的扩增水平与鼻腔鼻窦鳞癌的发生有关，与癌前期病变转化为恶性肿瘤有关。因而，ｃ－ｍｙｃ的水平可能作为临床鼻腔鼻窦鳞癌的分子水平诊断和检测鼻腔内翻性乳头状瘤是否有恶变倾向的一种参考指标。
AIM: To study the relationship between the c- myc amplification and squamous cell carcinoma inverted papilloma in nasal cavity and nasal sinus.METHODS:44 samples (24 cases of squamous cell carcinoma in nasal cavity and nasal sinus; the benign tumors are 15 cases which are 8 cases of inverted papilloma in nasal cavity, 5 cases of angioma in nasal cavity, 2 cases of maxillary cyst and 5 cases of normal tissue in nose) are studied by moleculobiologic technique. RESULTS:Amplification of c- myc in all of cases as follows: 10～40 times in malignant tumors, 5～10 times in inverted paplilloma, 5 times below in begin tumors and normal tissues. CONCLUSION: Amplificated level of c- myc as a molecular parameter might be used to detect whether inverted paplilloam in nasal cavity were changing into malignance early. The amplification of c- myc is responsible for the squamous cell carcinoma in nasal cavity and nasal sinus.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第5期418-420,共3页
Chinese Journal of Pathophysiology
基金
广东省自然科学基金
关键词
鼻肿瘤
鳞癌
C-MYC基因
基因扩增
Nasal cavity
Paranasal sinuses
Carcinoma, squamous cell
Oncogenes
