摘要
目的：观察培哚普利对早期糖尿病肾病（ＤＮ）肾脏前列腺素代谢的影响，探讨培哚普利防治ＤＮ的机制。方法：４４例无高血压、持续有微量白蛋白尿的Ⅱ型糖尿病患者随机分为培哚普利治疗组和常规治疗组。１５例正常人为正常对照组。结果：培哚普利治疗８周后ＤＮ患者尿６－ｋ－ＰＧＦ１α、ＰＧＥ２排泄分别增加２８．１％、２４．５％（Ｐ＜０．０５），而对ＴＸＢ２排泄无影响；常规治疗对尿前列腺素排泄无影响。结论：培哚普利对ＤＮ肾功能的保护作用和其介导肾脏ＰＧＥ２、ＰＧＩ２合成分泌密切相关。
Objective: To investigate the effects of perindopril on metabolism of prostaglandins in kidneys at the early stage of diabetic nephropathy (DN) to explore the mechanism of prevention and treatment of DN with perindopril. Methods: Forty four cases of non insulin dependent diabetes mellitus with microalbuminuria and normatension were randomized into the routinely treated group (RTG) and perindopril treated group (PTG). Results: Eight weeks after the treatment, the excretion of urinary 6 keto prostaglandin F 1α and prostaglandin E 2 (PGE 2) was increased by 28.1% and 24.5% respectively while the excretion of urinary thromboxane B 2 remained stable in PTG. In RTG, no significant changes were found. Conclusion: Perindopril might protect renal function in patients with DN through increasing the production of prostacyclin and PGE 2.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第4期288-290,共3页
Journal of Third Military Medical University
