摘要
目的：探讨血液ＡＦＰｍＲＮＡ在复发性肝癌及伴有肝外远处器官转移的原发性肝癌中的表达及意义。方法：应用巢式ＲＴ－ＰＣＲ检测４０例复发性肝癌及伴有肝外远处器官转移的原发性肝癌血液ＡＦＰｍＲＮＡ。结果：２１例伴有肝外远处器官转移的原发性肝癌血液ＡＦＰｍＲＮＡ均表达阳性（１００％），１９例复发性肝癌患者中有７例血液ＡＦＰｍＲＮＡ表达阳性（３６．８％），两组比较差异有显著性意义（Ｐ＜０．０１）。结论：血液ＡＦＰｍＲＮＡ有希望成为判断肝癌复发或预测肝癌远处器官转移的客观性指标之一。
Objective: To study the expression of blood AFP mRNA in patients with recurrent or distant metastasis of human hepatocellular cacinoma (HCC). Methods: We examined 40 blood samples from patients with recurrent or distant metastasis HCC by nested RT PCR to find out AFP mRNA. Results: AFP mRNA was detected in 7 blood samples from 19 HCC with recurrent HCC (36.8%) and in all HCC patients with distant metastasis(100%). Conclusions: AFP mRNA may be used as a marker of HCC recurrent and metastasis.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第3期192-193,共2页
Academic Journal of Second Military Medical University
