摘要
目的：研究复方丹参注射液在治疗慢性原发性肾小球肾炎中的作用。方法：４５例患者分为２组，常规治疗组１９例（用雷公藤多苷片、潘生丁片、保肾康片治疗）；常规＋丹参组２６例（在常规治疗组用药基础上加复方丹参注射液静脉点滴）。观察治疗前后血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）水平。结果：慢性肾炎患者血浆ＥＴ水平高于正常人（Ｐ＜０．０１），而ＣＧＲＰ水平低于正常人（Ｐ＜０．０１），治疗后均显著改善（Ｐ＜０．０１），且以常规治疗＋丹参组改善更为显著，与常规治疗组治疗后比，Ｐ＜０．０１。结论：复方丹参注射液能改善慢性肾炎患者ＥＴ、ＣＧＲＰ的代谢失衡状态。
OBJECTIVE :To study the compound injection of salvia miltiorrhizae (IS) in treating chronic primary glomerulone phritis (CPP) diseases. METHODS :Patients with CPP diseases were divided into two groups:usual medicine treatment group (treated with multi glycosides of triptery gium wilfordii,persatin,baoshenkang et al);usual medicine and IS treatment group (treated with usual medicine and IS et al).The plasma ET CGRP levels were observed before and after treatment,and also controled with normals. RESULTS :The level of ET of CPP patients was higher than that in normal group before treatment (P<0.01),and the level of CGRP was lower (P<0.01).The changes of ETCGRP before and after treatment were signifficant (P<0.01),the improvment of ETCGRP in usual medicine and IS treatment group was better than that in the usual medicine treatment group (P<0.01).CONCLUSIONS :IS had the ability of improving the unblance of ETCGRP in patients with CPP diseases
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1999年第5期264-265,共2页
Chinese Journal of Hospital Pharmacy
关键词
复方丹参注射液
肾小球肾炎
内皮素
CGRP
compound salvia miltiorrhizae injection
chronic primary glomerulone phritis
endothelin
calcitonin gene related peptide
