摘要
目的:观察戊乙奎醚对丙泊酚伍用氯胺酮静脉麻醉用于小儿无痛肠镜检查中的影响。方法:选择行无痛肠镜检查的患儿72例,男38例,女34例,随机分为阿托品-丙泊酚-氯胺酮静脉麻醉组(A组)及戊乙奎醚-丙泊酚-氯胺酮静脉麻醉组(B组)。每组各36例。记录意识消失时间、苏醒时间(停止用药至能正确应答的时间)、丙泊酚的用药量及氯胺酮的用药量,统计镜检中肢体扭动的发生率、因口腔分泌物增多致上呼吸道梗阻的发生率及术后恶心呕吐的发病率。结果:麻醉苏醒时间A组显著长于B组(P<0.05)。氯胺酮及丙泊酚的用药量A组显著多于B组(P<0.05)。镜检中A组6例(16.7%)患儿术中出现口腔分泌物增多,一度出现轻度上呼吸道梗阻,经吸痰加给氧后缓解;B组3例(8.3%)患儿术中出现上呼吸道梗阻,经减轻麻醉后梗阻缓解,与A组比较存在显著性差异(P<0.05)。镜检后恶心呕吐的发病率A组显著高于B组(P<0.01)。两组患儿镜检中未见明显的肢体扭动发生。结论:戊乙奎醚可较有效地改善丙泊酚伍用氯胺酮静脉麻醉效果,戊乙奎醚-丙泊酚-氯胺酮静脉麻醉技术可安全有效地应用于小儿无痛肠镜检查中。
Objective：To observe the effects of penehyclidine hydrochloride on intravenous anesthesia combine propofol and ketamine for the children＇s colonoscopy.Methods：Seventy two children were divided randomly and averagely into two groups.Group A received combined atropine-propfol–ketamine intravenous anesthesia.Group B received combined penehyclidine hydrochloride-propfol-ketamine intravenous anesthesia.Off brain time,wakeup time,propofol dosage,ketamine dosage,the rate of upper airway obstruction of children and the rate of postoperative nausea and vomiting were recorded.Results：The wake-up time of group A was longer than that of group B（P0.05）.The dosage of ketamine and propofol in group A was significantly more than that in group B（P0.05）.The rate of upper airway obstruction was due to increased oral secretion in group A,it was significantly higher than that in group B（P0.05）.The rate of postoperative nausea and vomiting was higher than that in group B（P0.01）.Conclusion：Penehyclidine hydrochloride combined propfol and ketamine can effectually improve the effect of intravenous anesthesia for children＇s colonoscopy.Combined penehyclidine hydrochloridepropfol-ketamine intravenous anesthesia was feasible and safe.
出处
《中日友好医院学报》
2010年第5期286-288,共3页
Journal of China-Japan Friendship Hospital
关键词
戊乙奎醚
丙泊酚
氯胺酮
静脉麻醉
小儿结肠镜检查
penehyclidine hydrochloride
propfol
ketamine
intravenous anesthesia
children＇s colonoscopy
