摘要
目的探讨肺硬化性血管瘤的临床病理特点。方法对15例肺硬化性血管瘤进行临床病理、免疫组化研究。结果肺硬化性血管瘤由实性细胞区、乳头状区、肺泡内出血及硬化性改变组成。被覆乳头表面、实性区裂隙及血管样腔面的立方细胞；实性区及乳头轴心为形态一致的圆形、多边形胞浆浅染细胞。免疫组化示：两种细胞均表达TTF1，立方细胞表达CK、EMA；而浅染圆形细胞表达Vimentin，部分表达NSE和Syn。结论肺硬化性血管瘤可能起源于肺泡Ⅱ型细胞或呼吸道的原始的多潜能干细胞。
Objective To study the clinicopathological characteristics of sclerosing hemangioma of the lung （SHL） Methods Fifteenth cases of SHL were investigeted by light microscopy and immunohistochemistry. Results The tumor showed a mixture of the following four histological patterns, solid, papillary, Intra-alveolar hemorrhage and sclerotic change.Cuboidal cells covered the papillary projections and cleftslide spaces in solid areas whereas solid areas and the stalk of papillary projections were composed of uniform, round or polygonal pale cells.Immunohistochemistry staining revealed that the surface of the cuboidal cells expressed TTF1, CK, EMA, and the round , pale cells expressed TTF1, vimentin, some NSE, Syn. Conclusion SHL may originate from the pulmonary alveolar II cell or primitive respiratory multipotent stem cell.
关键词
肺
硬化性血管瘤
临床与病理
免疫组织化学
Lung
Sclerosing hemangioma
Clinic and opathology
Immunohistochemistry
