摘要
目的探讨尿碘与甲状腺疾病的关系。方法采用酸消化砷铈催化分光光度法和放免方法，测定了我院364例甲状腺疾病患者和50例健康者的尿碘和血清甲状腺激素水平。结果甲亢患者尿碘中位数（MUI）为465μg／L，甲减患者MUI为487μg／L，单纯性甲肿患者MUI为332μg／L，正常人MUI为296μg／L，并且从频数分布图中可以看出当尿碘值大于300时，甲状腺疾病的发病率明显增加，尤其是甲亢组和甲减组更明显；甲亢组中有169例为GD，甲减组中有48例为HT，GD组MUI为498μg／L，HT组MUI为502μg／L，而正常组MUI为296μg／L，与对照组相比均有统计学意义（P〈0．05），另外HT组TGAb在60%以上；HT患者中TGAb、TPOAb明显高于正常者。以尿碘为因变量进行多元逐步回归分析发现，尿碘与TGAb、TPOAb呈明显正相关，其中与TGAb相关性最大，与FT4呈负相关。结论提示甲状腺疾病发病率高与碘的摄入高有关。常规检测尿碘能提高甲状腺疾病的早期诊治率。
Objective To investigate the relationship between thyroid diseases and urine iodineo Methods Unnary specimens of me 364 thyroid patients in our hospital and the 50 healthy subjects were collected to detect urinary iodine and thyroxin level in serum by way of the contact of acid digestion arsenic-cerium and radio-immunity determination. Results The median value of urinary iodine （MUI） in the four groups （hypothyroidism patients, hyperthyroid patients, simple goiter patients and normal controls） were 465μg/L, 487μg/L, 332μg/L and 296μg/L respectively, from the frequency distribution, the incidence of thyroid diseases increased remarkably when the urinary iodine values〉300μg/L （particularly hyperthyroidism group and hypothyroid group ）. 169 case of GD in hyperthyroidism group （MUI = 498μg/L）, while 48 case of HT in hypothyroid group （MUI = 502μg/L）, were both significantly higher than those in normal controls （MUI =296μg/L, P〈0.05 ）. In addition, the level ofTGAb, TPOAb in HT case were higher than normal range （TGAb〉 60% ） . Multivariate regession analysis indicated that urine iodine were still negetivelycorrelated with FT4 and positively correlated with TGAb, TPOAb, among them, TGAb was the maximal correlation.Conclusions The incidence of thyroid diseases is related to iodine intake. It is regarding that the routine testing of urine iodine is necessary to improve the correct diagnose rate in the early period of the disease.
关键词
甲状腺
尿碘
thyroid, urine iodine
