摘要
目的探讨纤维蛋白原（fibrinogen，FIB）与支架内再狭窄的相关性。方法选择2007年8月～2009年12月曾在我院植入火鸟支架（firebird各型药物支架，上海微创公司生产）并于3～12个月内完成了冠脉造影复查的64例患者为研究对象，根据有无支架内再狭窄分为再狭窄组（n=13）和无再狭窄组（n=51）。术前检测血清FIB、甘油三酯（tfiglycende，TG）、总胆固醇（total cholesterol，TC）、高密度脂蛋白酯（high density lipoprotein cholesterol，HDL—c）、低密度脂蛋白酯（low—density lipoprotein cholesterol，LDL—c）、载脂蛋白A1（apolipoprotein A1，ApoA1）、载脂蛋白B（apolipoprotein B．ApoB）。比较FIB在两组间有无差异。并且对FIB与再狭窄进行偏相关分析及多元逐步回归分析。结果1．FIB在术后支架内再狭窄组明显高于无再狭窄组（P〈0．001）。2．多元线性回归分析发现，FIB与再狭窄的相关性是除TC外的第二个最强指标（p〈0．001）。结论FIB与支架内再狭窄相关。
Objectives： To explores the relationship between serum fibrinogen （FIB） and in-stent restenosis by using coronary angiography and measuring the serum FIB .Methods： In the study 64 patients with CHD and implanting stent were selected in the department of cardiology in affliatted hospital from August, 2007 to December , 2009.After admission all candidates underwent coronary angiography and their serum FIB were determined. According to the result of coronary angiography all the subjects were divided into 2 groups： in-stent restenosis group （n=13） and no in-stent restenosis group （n=51） . the study also shows the intensity of the dependability by multivariate regression .Results： 1 The levels of serum FIB in ISR group is higher than that in no in-stent restenosis （ISR） group. 2 The multivariate regression analysis showed that the serum FIB is correlated with CSS , the amount of stenosis vessel and ISR. Conclusions： The levels of FIB is related to ISR.
关键词
冠心病
冠状动脉造影
纤维蛋白原
血脂
支架内再狭窄
Coronary heart disease
Coronary angiography
Plasma lioids
Fibrinogen
In-stent restenosis
