摘要
目的了解胎儿宫内发育迟缓（ＩＵＧＲ）时胎盘病理改变与母血及脐血中一氧化氮（ＮＯ）水平的关系。方法对１９９７年１１月～１９９８年１０月３８例妊娠合并胎儿宫内发育迟缓（ＩＵＧＲ组）及３０例正常孕妇（对照组）分娩后的胎盘及胎儿附属物进行分析。用隔还原显色法测定母血及脐血ＮＯ水平。结果ＩＵＧＲ组中２６例有胎盘、脐带病理改变（６８．４２％）。主要表现为绒毛发育迟缓及绒毛炎；对照组中５例有胎盘病理改变（１６．６７％），两组比较差异有极显著性（Ｐ＜０．０１）；ＩＵＧＲ组中母血及脐血ＮＯ水平均低于对照组（Ｐ＜０．０５，Ｐ＜０．０１）；ＩＵＧＲ组中２６例胎盘病理改变明显，其母血及脐血ＮＯ水平低于胎盘无明显病理改变者（Ｐ＜０．０５，Ｐ＜０．０５）；两组脐血ＮＯ水平均高于母血ＮＯ水平（Ｐ＜０．０１，Ｐ＜０．０５），两组脐血与母血ＮＯ水平均有相关性（ｒ＝０．５４７５，ｒ＝０．８５０６）；脐血ＮＯ水平与新生儿体重在ＩＵＧＲ组未发现明显相关性（ｒ＝０．２８３８）。结论ＩＵＧＲ时，胎盘发生明显病理变化，导致母血及脐血中ＮＯ的水平降低。
Objective To study the relation between placental pathologic changes and levels of maternal and umbilical serum nitric oxide (NO) in intrauterine growth retardation (IUGR). Methods 38 patients with IUGR (IUGR group) and 30 healthy pregnant women in their late trimester (control group) were studied from Nov.1997 to Oct.1998. The placenta and the appendages of fetus were studied after delivery. The concentration of serum NO were determined with cortas' method. Results Placental pathological changes were found in 26 cases of IUGR group (68.42%), and the main pathological changes were growth retardation of villi and villositis. In the control group, 5 out of 30 cases had placental pathological findings (16.67%). There was statistically significant difference between the 2 groups ( P <0.01). In IUGR group, the maternal and umbilical NO concentration in the 26 cases with placental pathological changes decreased significantly when compared with that in 12 cases without obvious pathological findings of placenta ( P <0.05, P <0.05); NO levels of umbilical cord were higher than that of maternal serum in both groups( P <0.01, P <0.05); There was correlation about serum NO concentration between mother and her fetus in both groups ( r =0.547 5, r =0.850 6); but umbilical serum NO level was not related to the weight of the newborn ( r =0.283 8). Conclusion The obvious placental pathologic changes occurred in patient with IUGR caused noticeably lower NO levels in maternal and umbilical serum.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1999年第4期217-219,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
胎儿发育迟缓
病理学
胎盘
一氧化氮
Fetal growth retardation
Pathology
Placenta
Nitric oxide
