摘要
传统的血肌酐、尿素氮、尿量等指标不能反映急性肾损伤早期变化,近年来,随着检测技术的进步,多种能反映早期肾损伤的标志物被发现。该文对肾损伤分子1、中性粒细胞明胶酶相关脂质运载蛋白、白介素18、钠氢交换体亚型3、脂肪酸结合蛋白等尿生物标志物结构特征、代谢特点、临床意义进行综述。
Traditionally the most widely used biomarkers for the early detection of acute kidney injury are proteinuria, serum creatinine, and blood urea nitrogen. All of these are less optimal and tend to focus attention on later stages of injury when therapies may be less effective. Recently, there has been a great surge of interest in identifying novel biomarkers that can be easily detected in the urine and can diagnose renal injury at the earliest stages. A variety of methods have been employed to identify these biomarkers, including proteomics, metabolomics, and gene arrays. Currently, several candidate biomarkers have been identified and studied. These include kidney injury molecule-1 （KIM-1）, neutrephil gelatinase-assoeiated lipocdin （ NGAL）, interleukin （IL） -18, Sodium Hydrogen exchanger isoform 3 （NHE3） and fatty-acid binding proteins （FABPs）. This review will highlight the current state of knowledge of these biomarkers as well as the limitation of these biomarkers in the early diagnosis of renal injury.
出处
《中国临床新医学》
2010年第9期902-905,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广西科技厅自然基金课题(桂科自0640055)
