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胃癌的表观遗传学研究进展 被引量:2

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摘要 胃癌的发生发展是一个涉及多基因多步骤的复杂过程,包括遗传机制以及表观遗传学修饰两个方面。表观遗传学修饰在胃癌发生过程中的作用越来越受到重视。异常甲基化通过影响基因转录,促基因突变,增加染色体结构的不稳定性等多方面促进胃癌的发生发展。组蛋白的乙酰化影响着抑癌基因的转录,从而在胃癌的发生进展中发挥着重要作用。
作者 彭小春 魏蕾
出处 《长江大学学报(自科版)(下旬)》 CAS 2010年第3期65-69,共5页 Journal of Yangtze University
基金 湖北省教育厅科学技术研究项目(Q20081210)
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