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两亲性温敏嵌段共聚物P(NIPAAm-co-DMAAm)-b-PLA的合成与表征 被引量：2

Preparation and Characterization of Thermosensitive Amphiphilic Block Copolymer Based on Poly(N-isopropylacrylamide-co-N,N'-dimethyl acrylamide)-b-poly(I-lactide)
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摘要 合成了一种温敏性嵌段两亲性共聚物P(NIPAAm-co-DMAAm)-b-PLA。通过自由基聚合的方法制备了一种含端羟基的N-异丙基丙烯酰胺(NIPAAm)和二甲基丙烯酰胺(DMAAm)的温敏性无规共聚物,利用端羟基开环丙交酯得到两亲性嵌段共聚物P(NIPAAm-co-DMAAm)-b-PLA。核磁氢谱的结果验证了嵌段共聚物的成功合成,此两亲性共聚物在水中可以自组装成胶束,采用可控温的紫外可见分光光度计表征了其温敏性能,测量结果表明,嵌段共聚物显示了较好的温度敏感特性,相转变温度LCST被成功地调节到40℃以上。此嵌段共聚物兼具良好的温度敏感特性,将在药物缓释方面具有良好的应用前景。 A kind of thermosensitive block copolymer P（NIPAAm-co-DMAAm）-b-PLA is designed. Using free radical polymerization a hydroxyl terminated copolymer composed of N-isopropylacrylamide（NIPAAm） and N, N＇- dimethyl acrylamide（DMAAm） is prepared, then the goal block copolymer is synthesized by the ring opening poly- merization of L-lactide. The polymer obtained is characterized by ^1H-NMR and FTIR spectroscopy. The results exhibit the temperature sensitivity with a lower critical solution temperature（LCST） above 40℃ in water, which can potentially be used as a drug carrier in biomedical field.
作者 曹阳 任杰 徐敏明
机构地区 同济大学材料科学与工程学院纳米与生物高分子研究所
出处 《材料导报》 EI CAS CSCD 北大核心 2010年第18期112-114,共3页 Materials Reports
基金 国家自然基金资助项目(20804029)
关键词 温敏性 两亲性共聚物 药物载体 thermosensitivity, amphiphilie copolymer, drug carrier
分类号 O633 [理学—高分子化学]
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参考文献4

  • 1Nakayama M, et al. Molecular design of biodegradable polymeric mieelles for temperature-responsive drug release[J]. J Control Release, 2006,115(1) : 46.
  • 2Wei H, Wu D Q, Li Q, et al. Preparation of shell crosslinked thermoresponsive micelles as well as hollow spheres based on P(NIPAAm-co-HMAAm-co-MPMA)-b-PCL[J]. J Phys Chem C, 2008,112(39): 15329.
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  • 2SASATSU M,ONISHI H,MACHIDA Y. Preparation of a PLA-PEG block copolymer using a PLA derivative with a formyl terminal group and its application to nanoparticulate formulation[J].International Journal of Pharmaceutics,2005,(1-2):233-245.
  • 3VINK E T H,RABAGO K R,GLASSNER D A. Applications of life cycle assessment to NatureWorksTM polylactide (PLA) production[J].Polymer Degradation and Stability,2003,(03):403-419.doi:10.1016/S0141-3910(02)00372-5.
  • 4LUO Y B,WANG X L,WANG Y Z. Effect of TiO2 nanoparticles on the long-term hydrolytic degradation behavior of PLA[J].Polymer Degradation and Stability,2012,(05):721-728.
  • 5RILEY T,GOVENDER T,STOLNIK S. Colloidal stability and drug incorporation aspects of micellar-like PLA-PEG nanoparticles[J].Colloids and Surfaces B:Biointerfaces,1999,(1-4):147-159.
  • 6VILA A,GILL H,MCCALLION O. Transport of PLA-PEG particles across the nasal mucosa:Effect of particles size and PEG coating density[J].Journal of Controlled Release,2004,(02):231-244.
  • 7LU Y,LI J,WANG G J. In vitro and in vivo evaluation of mPEG-PLA modified liposomes loaded glycyrrhetinic acid[J].International Journal of Pharmaceutics,2008,(1-2):274-281.
  • 8王学松.现代膜技术及其应用指南[M]北京:化学工业出版社,200513-51.
  • 9FU X Y,MARUYAMA T,SOTANI T. Effect of surface morphology of fouling by humic acid with the use of cellulose acetate butyrate hollow fiber membranes[J].Journal of Membrane Science,2008,(1-2):483-491.
  • 10SASATSU M,ONISHI H,MACHIDA Y. Preparation and biodisposition of methoxypolyethylene glycol amine-poly (DL-lactic acid) copolymer nanoparticles loaded with pyrene-ended poly (DL-lactic acid)[J].International Journal of Pharmaceutics,2008,(1-2):271-277.

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材料导报
2010年 第18期

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