摘要
目的：观察顺式阿曲库铵的肌松效应，并与阿曲库铵相比，以了解该药在国人的作用特点。方法：ＡＳＡⅠ～Ⅱ级择期手术病人３０例，随机分为三组，每组１０例，分别予顺式阿曲库铵０１ｍｇ／ｋｇ（Ｃｉｓ１组），０１５ｍｇ／ｋｇ（Ｃｉｓ２组）和阿曲库铵０５ｍｇ／ｋｇ（Ａｔｒ组），诱导麻醉，观察心率、血压和全身皮肤情况以及ＴＯＦ的变化。结果：顺式阿曲库铵０１ｍｇ／ｋｇ、０１５ｍｇ／ｋｇ与阿曲库铵０５ｍｇ／ｋｇ均未引起心率、血压明显变化与皮肤潮红。肌松起效时间分别为５６±０９、４０±０８和２５±０６，差别具有显著性（Ｐ＜００１）；临床作用时间分别为４０±２５、４５６±９２和３８４±４５；２５％～７５％的恢复指数分别为１０８±１１、１２６±２９和９８±３０，无统计学差异。结论：顺式阿曲库铵肌松效应与阿曲库铵相似，均为中时效。同等强度剂量相比，前者起效较慢。但增加剂量可使其起效加快。两者肌松恢复过程相似，无蓄积作用。
Objectives:Cisatracurium is one of the ten isomer of atracurium. Both the preclinical and
premier clinical studies have suggested that it may be relatively an ideal intermediate
nondepolarizing muscle relaxant. However, repeated studies are required to find out its
advantages and disadvantages, especially by comparing with atracurium. The purpose of the
present study is to evaluate its neuromuscular blocking effects by comparing with atracurium.
Methods: 30ASA patients undergoing selective surgery under nitrous oxide/opioid/propofol
anesthesia were randomly allocated into three groups: Cis1(n=10)Cis2(n=10) and Atr(n=10).
Cisatracurium 01mg/kg(2ED95)015mg/kg(3ED95) or atracurium 05mg/kg(2ED95) was given
respectively. HR BP skin flushing and TrainofFour(TOF) reponse of the adductor pollicis muscle
following supramaximal electrical stimulation of the ulnar nerve were monitored until T4T107.
Results: No significant changes of HRBPwere found in three groups. Onset time of Cis1Cis2
and Atr were5609scular block4008and 2506, clinical duration were 4002545692 and 38445,
respectively. 25%75% recovery index was 1081112620and 9830respectively. Conclusion: At
equipotent dose, the onset time of cisatracurium is slower than that of atracurium but lager dose
can reduce the difference. They have a similar recovery profile and show no accumulation.
出处
《临床麻醉学杂志》
CAS
CSCD
1999年第3期137-138,共2页
Journal of Clinical Anesthesiology
