摘要
用小鼠作急性毒性实验，汉丹肝乐的最大灌胃量达２４ｇ／ｋｇ·ｄ，为临床用药量的４００倍，７ｄ观察期内未见明显毒性反应及动物死亡；用大鼠作长期毒性实验，汉丹肝乐口服每天用量为０６ｇ／ｋｇ、１５ｇ／ｋｇ、３０ｇ／ｋｇ，分别为临床用药的１０倍，２５倍和３０倍，２４周观察期内各组动物一般状况良好，血象、肝肾功能均在正常范围内，主要脏器肉眼尸检及组织学镜检未见明显病理反应，观察期内无一动物死亡，表明本品口服安全无毒。
Han-Dan-Gan-Le (HDGL), a Chinese Medicine preparation composed of Stephania tetrandra, Salvia miltorrhiza, Radix paeoniae, Astragalus membranaceus, and Ginkgo leaf, has been used successfully to treat human liver fibrosis. This study was designed to investigate the safety of HDGL. Acute and Long-period toxicological investigations were carried out on mice and rats respectively. The result indicated that mice given HDGL 24 g/kg·d (this dose is 400 times of that clinical application), po, for 7 dads showed no toxic action and no one died. The result also indicated that the common condition hemogram and function of liver and kidney are normal, autopsy and histopathological examination haven't found pathological change, when rats were given HDGL 0 6 g/kg, 1 5 g/kg and 3 0 g/kg(these doses are 10, 25and 50 times that of clinical application), po, daily for 24 weeks. In conclusion, HDGL is safe when used,po, at the recommended dose and treatment period.
出处
《贵阳医学院学报》
CAS
1999年第2期134-135,138,共3页
Journal of Guiyang Medical College
基金
贵州省科委"九五"攻关项目
