摘要
目的：研究风湿性心脏病（ＲＨＤ）心衰时心室肌中肌球蛋白轻链（ＶＭＬＣ）的变化与心脏重塑的关系。方法：采用Ｗｅｓｔ－ｅｒｎｂｌｏｔｉｎｇ技术对１３例ＲＨＤ心衰患者及７例意外死亡者ＶＭＬＣ－１，ＶＭＬＣ－２含量进行定量分析。结果：ＲＨＤ组ＶＭＬＣ－１，ＶＭＬＣ－２含量均显著低于正常对照组，以ＶＭＬＣ－２含量下降最明显，ＶＭＬＣ－１／ＶＭＬＣ－２比值在１∶０．９５～１∶０．６１。结论：ＲＨＤ心衰发展过程中涉及了ＶＭＬＣ－１，ＶＭＬＣ－２蛋白水平的改变，这种改变可能对心功能的进行性恶化有直接影响。
Objective: To study the changes of ventricular myosin light chain (VMLC) and its relation with heart remodeling in rheumatic heart disease (RHD). Methods: Using Western blotting hybridization assay, we detected VMLC1, VMLC2 in 13 patients with RHD and 7 cases of accidental deathes. Results: As compared with the normal group, the contents of VMLC1 , VMLC2 were all decreased significantly in RHD patients, especially the VMLC2. The ratio of VMLC1/VMLC2 in RHD patients varied from 10.95 to 10.61. Conclusion: The values of VMLC1, VMLC2 and the ratio of VMLC1/VMLC2 are all changed during the development of heart remodeling in RHD patients, suggesting that these changes may exert a direct effect on the progressive deterioration of heart function.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第5期325-326,共2页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
