摘要
目的：观察吲达帕胺治疗中枢性尿崩症的疗效并初步探讨其作用机制。方法：采用随机区组设计，对８例中枢性尿崩症患者轮流给予吲达帕胺２５～７５ｍｇ·ｄ－１或卡马西平１５０～３００ｍｇ·ｄ－１或双氢氯噻嗪５０～７５ｍｇ·ｄ－１口服治疗，连续８ｄ，停药４ｄ，依次更换药物二次，动态观察尿量及水盐代谢指标。结果：三药在用药的第４ｄ，第８ｄ尿量均较用药前为低；吲达帕胺在用药的第４ｄ、第８ｄ血钾、血氯较用药前降低，肾性活性较用药前升高（Ｐ＜０．０５）。结论：吲达帕胺对中枢性尿崩症有抗尿崩作用。
Objective: To investigate the efficacy and antidiuretic mechanism of indapamide in
central diabetes insipidus. Methods: We observed eight patients with central diabetes insipidus
treated by indapamide (2.5～7.5mg·d -1 ) or dihydro chlorothiazide (50～70mg·d -1 ) or
carbamazepine (150～300mg·d -1 ) for 8 days with randomized block design. The therapy
was changed twice in sequence after 4 days without treatment. Urine output and indexes of
water metabolism were also observed. Results: The urine output was reduced on the 4th day
and 8th day with each therapy. The serum potassium and chloride concentration was decreased
and renin activity was increased on the 4th and 8th day with indapamide therapy. Conclusion:
Indapamide has antidiuretic action on central diabetes insipidus. The action may result from the
changes of hydroelectrolytes and renin angiotensin aldosterone system.
出处
《湖南医科大学学报》
CSCD
1999年第3期259-262,共4页
Bulletin of Hunan Medical University
关键词
尿崩症
吲达帕胺
药物疗法
中枢性
diabetes insipidus
indapamide *
drug effects
drug therapy
therapeutic use
physiopathology
