摘要
目的对辽细辛地下部分进行化学成分研究。方法采用反复硅胶柱色谱法分离纯化,通过理化性质和谱学分析鉴定化合物结构。结果分离得到6个化合物,分别鉴定为马兜铃酰胺Ⅰ(aristololactamⅠ,1)、7-甲氧基马兜铃酰胺(7-methoxy-aristololactam,2)、马兜铃酸Ⅳa(aristolochicacidⅣa,3)、对羟基苯甲酸(p-hydroxybenzoic acid,4)、5,7-二-O-β-D-吡喃葡萄糖基柚皮素(5,7-di-O-β-D-glucpyranosyl-narigenin,5)、2,6-二甲氧基-4-甲基苯基-1-O-β-D-吡喃葡萄糖苷(2,6-dime-thoxy-4-methylphenyl-1-O-β-D-glucopyranoside,6)。结论化合物4、6为细辛属内首次分离得到,化合物2、5为从该植物中首次分离得到。
Objective To study the chemical constituents from the roots of Asarum heterotropides Fr Schmidt.var.mandshuricum（Maxim.）Kitag.Methods The compounds were isolated by chromatography on silica gel columns and identified on the physical-chemical properties along with spectral analysis.Results Six compounds were obtained and identified as aristololactamⅠ（1）,7-methoxy-aristololactam（2）,aristolochic acid Ⅳa（3）,p-hydroxybenzoic acid（4）,5,7-di-O-β-D-glucpyranosyl-narigenin（5）,2,6-dimethoxy-4-methylphenyl-1-O-β-D-glucopyranoside（6）.Conclusions Among them,compounds 4 and 6 are isolated from Asarum genus for the first time,and compounds 2 and 5 are isolated from this plant for the first time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2010年第9期707-710,共4页
Journal of Shenyang Pharmaceutical University
基金
国家科技支撑计划子课题资助项目(2006BAI06A00)
关键词
辽细辛
化学成分
地下部分
结构鉴定
Asarum heterotropides Fr Schmidt.var.mandshuricum（Maxim.）Kitag.
chemical constituent
root
structure identification
