摘要
［目的］探讨金克（槐耳颗粒）在复发性中、高度恶性非霍奇金淋巴瘤（NHL）再化疗中应用的疗效。［方法］选用有明确病理诊断且既往用过化疗的复发性非霍苛金淋巴瘤共36例，随机分为两组，进行前瞻性对比治疗。两组均采用相同的CHOP方案化疗。治疗组18例用金克联合化疗，对照组18例单用化疗，分别评定近期疗效，T细胞亚群分布状态，毒副反应。［结果］治疗组CR率为61．0％，对照组为33.0％，差异有显著性（P＜0．05）。治疗组化疗后T细胞亚群中CD3、CD4水平明显高于对照组（P＜0．01）。毒副反应治疗组较对照组明显少而轻（P＜0．05）。［结论］金克在复发的NHL再化疗中应用有较好的疗效，值得临床上进一步应用与探讨。
[Purpose] To study the effect of Jinke based combination chemotherapy for recurrent high-grade Non Hodgkins lymphoma(NHL).[method]Thirty-six cases with recurrent NHL pathologically proved and previous chemotherapy were randomized divided into 2 groups. The treatment group received CHOP regimen with Jinke(18 cases). The control group received CHOP regimen alone. The short term complications, the distribution of T cell sub-group, and side effects were evaluated. [Results] The complete response (CR) rates in the treatment group and the control group were 61 .0% all 33 .0%, respectively. The difference was statistically significant (P < 0.05) .Thfe post-chemotherapy levels of CD3 and CD4 in T cell sub-groups of the treatment group were significantly higher than that in the control group(P<0.01), while the side effect was lower than that in the control group (P < 0.05). [Conclusion] Jinke has good efficacy on re-chemotherapy in recurrent NHL cases. Furthur study and exploration will be needed.
出处
《中国肿瘤》
CAS
1999年第5期237-238,共2页
China Cancer
