摘要
目的优化磷酸川芎嗪鼻用pH敏感型原位凝胶的制备工艺。方法采用星点设计法考察卡波姆和羟丙基甲基纤维素的用量对制备工艺的影响,以黏度和5h的药物释放量作为考察指标,对结果进行线性方程和二次多项式方程拟合,效应面法选取最佳工艺条件进行预测分析。结果从复相关系数上看,各指标二项式拟合方程均优于多元线性回归方程,优选的最佳条件为卡波姆的用量为0.55%,羟丙基甲基纤维素的用量为1.4%。结论星点设计-效应面法适用于磷酸川芎嗪鼻用pH敏感型原位凝胶的工艺优化,所建立的数学模型预测性良好。
Objective To optimize the process of Ligustrazine Phosphate pH-sensitive in situ gels in nasal process.MethodsCentral composite design was used to observe the effect of the amount of carbopol and HPMC on preparation process with of viscosity and 5 h drug release as indicators,the results of linear equations and quadratic polynomial equation fitting,response surface method to select the optimum conditions for predictive analysis.ResultsAccording to multiple correlation coefficient,the indicators were better than the binomial equation fitting multiple linear regression equation,the best conditions for the optimization was the amount of carbopol 0.55%,the amount of HPMC 1.4 %.ConclusionThe central composite design and response surface method are useful for the optimization of preparing Ligustrazine phosphate pH-sensitive in situ gel in nasal.The estimation of the established model is good.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第9期2296-2298,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(No.30801551
30672669)
广东省自然科学基金(No.8451052005001186)
