摘要
目的观察尤瑞克林对急性脑梗死患者不同时期血液中神经元特异性烯醇化酶(NSE)的影响,探讨尤瑞克林对脑的保护作用。方法利用酶联免疫吸附法检测38例急性脑梗死患者尤瑞克林治疗过程中血清NSE水平,采用美国国立卫生院神经功能缺损评分量表(NIHSS)评定神经功能缺损程度,并与常规治疗组进行比较。结果尤瑞克林治疗组治疗后第3、7天血清NSE水平明显下降,低于常规治疗组(P<0.05);尤瑞克林治疗组NIHSS在治疗后第14天时明显低于常规治疗组(P<0.05)。结论尤瑞克林对脑神经元有保护作用,能有效改善急性脑梗死患者的神经功能缺损。
Objective To observe the effect of Urinary Kallidinogenase on neuron specific enolase（NSE） at different stages in patients with acute cerebral infarction（CI）,and to explore the protective mechanism of Urinary Kallidinogenase on neurons.Methods The NSE concentration was determined by enzyme-linked immunosorbent assay（ELISA） in 38 CI patients （group A）during Urinary Kallidinogenase treatment,and National Institutes of Health Stroke Scale （NIHSS） was recorded,clinical therapeutic effect evaluated,and compared with conventional therapy group （group B）.Results Serum NSE level of group A decreased significantly on days 3,7,lower than that of group B（P0.05）.NIHSS was significantly lower in group A than in group B on days 14 after treatment （P0.05）.Conclusion Urinary Kallidinogenase can protect neurons effectively and improve the neurological function defect in acute CI patients.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第26期2925-2927,共3页
Chinese General Practice
关键词
尤瑞克林
神经元特异性烯醇化酶
脑梗死
Urinary kallidinogenase
Neuron-specific enolase
Cerebral infarction
