摘要
目的 探讨醛固酮合成酶（CYP11B2）基因-344T/C多态性与蒙古族高血压的关系.方法 采用整群抽样的方法 ,选择内蒙古通辽市的1575名蒙古族居民作为研究对象,其中正常血压者417名,高血压前期者596例,高血压患者562例.对研究对象进行面对面问卷调查;采集血液标本;测量身高、体重、腰围、血压及血糖、血脂等指标,检测CYP11B2基因-344T/C的多态性.采用无序多分类反应变量logistic回归分析CYP11B2基因与高血压的关联.结果 蒙古族高血压前期和高血压粗患病率分别为37.84%（596/1575）和35.68%（562/1575）,高血压前期和高血压年龄标化患病率分别为38.57%和31.53%;正常血压组、高血压前期组及高血压组CYP11B2基因-344T的频率分别为0.66（481/728）、0.69（696/1042）和0.71（706/998）,C的基因频率分别为0.34（247/728）、0.33（346/1042）和0.29（292/998）.logistic回归分析结果 表明,CYP11B2基因与高血压前期有关联,TT、TC基因型相对于CC型的OR值分别为1.33（95%CI：0.87～2.01）和1.74（95%CI：1.13～2.67）,含TT或者TC基因型（TT＋TC）相对于CC型的OR值为1.49（95%CI：1.01～2.22）;CYP11B2基因与高血压有关联,含TT、TC基因型相对于CC型的OR值分别为1.70（95%CI：1.07～2.70）和1.59（95%CI：0.98～2.50）,含TT或者TC基因型（TT＋TC）相对于CC型的OR值为1.66（95%CI：1.06～2.58）.结论 CYP11B2基因-344T/C多态性与蒙古族原发性高血压的发生有关联.
Objective To explore the relationship between the -344T/C polymorphism of aldosterone synthase （CYP11 B2） gene and essential hypertension in Chinese Mongolian population. Methods By cluster-sampling method, a total of 1575 Mongolian people in Tongliao city of Inner Mongolia were included in this study. And 417 subjects were normotension, 596 subjects wereprehypertension and 562 subjects were essential hypertension. A survey was conducted to collect data by personal interview using a standard questionnaire, meanwhile fasting blood samples were drawn Height,weight,waist circumference,blood pressure,blood-fat indexes and fasting plasma glucose were measured. The variant genotypes of CYP11B2 were identified by PCR assays. The relationship between the - 344T/C polymorphism of CYP11 B2 gene and essential hypertension were analyzed by multinomial logistic regression model. Results Crude prevalence of prehypertension among Mongolian people was 37. 84% （596/1575）and hypertension was 35. 68% （562/1575）. The age-standardized prevalence of prehypertension was38.57% and hypertension was 31.53%. The frequency of the T and C allele was 0. 66 （481/728） and 0. 34 （247/728） for normotension group,0. 69 （696/1042） and 0. 33 （346/1042） for prehypertension group,0. 71 （706/998） and 0. 29 （292/998） for hypertension group. The multiple logistic models showed CYP11B2 variant genotypes were associated with prehypertension （TT/CC, OR = 1.33,95% GI： 0. 87-2.01; TC/CC, OR= 1.74,95% CI： 1.13 -2.67; TC ＋ TT/CC, OR= 1.49,95% GI： 1.01 -2.22）;CYP11B2 variant genotypes were associated with hypertension （TT/CC, OR = 1.70,95 % CI： 1.07 - 2.70;TC/CC,OR=1.59,95% CI： 0.98 -2.50; TC ＋TT/CC,OR=1. 66,95%CI： 1.06 -2.58）. Conclusion CYP11B2 gene -344T/C polymorphism were associated with essential hypertension in Chinese Mongolian population.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2010年第9期800-805,共6页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金（30360094）
关键词
醛固酮合酶
多态性
单核苷酸
高血压
蒙古族
LOGISTIC
模型
Aldosterone synthase
Polymorphism, single nucleotide
Hypertension
Mongolian nationality
Logistic models
