摘要
目的通过对无锡地区儿童过敏性紫癜患者急性期过敏物质的检测，了解其过敏状态及其过敏原构成情况，从而采取相应对策。方法选择246例急性发作期过敏性紫癜患者作为检测对象，均采用体外过敏原检测的方法，以德国Allergy Screen系统作为检测平台，检测血清特异性IgE和总IgE水平。结果246例过敏性紫癜患者中，血清过敏原特异性抗体IgE阳性反应者120例，占48．7％；其中对两种及两种以上过敏原反应阳性者86例，占34．9％；对一种过敏原反应阳性者34例，占13．8％。血清总IgE阳性（〉100kU／L）者194例，占78．9％；吸入组过敏原反应阳性者134例，占54．5％；其中尘螨、粉螨（19．1％），屋尘（17．1％），点青霉、交链孢霉（10．2％）较高。食物组过敏原反应阳性者77例，占31．3％；其中鱼肉（6．5％），蛋黄、蛋白（5．7％），羊肉（5．3％）较高。吸入组和食物组过敏原阳性率差异无统计学意义（χ^2=2．59，P〉0．05）。结论过敏性紫癜患者急性期过敏原多呈混合性，吸入类与食物类过敏原均与过敏性紫癜的发生有关，故需对相应的过敏原进行必要的避免，以减轻过敏原所带来的危害。
Objective To explore the allergic status and allergen composition in children with acute Henoch-Schonlein Purpura in Wuxi by allergen detection, thereby to establish appropriate therapeutic strategies. Methods Two hundred and forty-six patients with Henoch-Schonlein Purpura in their acute phase were examined for serum concentrations of total IgE and specific IgE using Germany AllergyScreen system. Results The positive rate of allergen-specific serum IgE was 48.7% （120/246） , of which,positive reactions to two or more than two allergens were found in 86 cases （34. 9% ） and that to one kind of allergen were found in 34 cases （ 13.8% ）. The positive rate of total serum IgE was 78.9% （ 194/246 ）. In inhalation allergen group, positive reaction to allergen was found in 134 cases （54. 5% ）. The most common allergen was dust mite/flour mites （ 19. 1% ）, and came the next were house dust（ 17.1% ） and Penicillium notatum/Alternaria alternata（ 10. 2% ）. In food allergen group,positive reaction to allergen was found in 77 cases （31.3%）. The most common allergen was fish （6, 5% ）, and came the next were egg （5.7%） and mutton （5.3%）. We found no significantly different allergen positive rates between inhalation allergens group and food allergens group （ χ^2 = 2. 59, P 〉 0. 05 ）. Conclusions The combined allergens attacks were more common in children patients with acute Henoch-Schonlein Purpura by serum allergen detection. Various types of the allergens are associated with the occurrence of acute Henoch-Schonlein Purpura. To reduce the harmness of allergens,it is necessary to avoid touching these allergens.
出处
《中国综合临床》
2010年第9期947-949,共3页
Clinical Medicine of China
