摘要
目的探讨胆红素及尿酸在颈动脉内膜增厚和斑块形成过程中的作用。方法根据超声检查颈动脉内膜中膜厚度，将2008年2月至2009年10月我科收治的162例缺血性脑血管病患者分成3组：对照组（50例）、颈动脉内膜增厚组（36例，内膜增厚组）和颈动脉斑块形成组（76例，斑块组）；用全自动生化仪分别进行血清结合胆红素、非结合胆红素、总胆红素和尿酸的测定。结果内膜增厚组尿酸（391．22±27．52）μmol／L较对照组（307．32±13．68）μmol／L和斑块组（327．84±17．96）μmol／L均明显升高（P均〈0．05）；非结合胆红素与总胆红素在斑块组[（10．96±0．58）、（15．91±0．71）μmol／L]较对照组[（14．17±0．97）、（19．88±1．21）μmol／L和内膜增厚组[（15．09±2．21）、（20．59±2．43）μmol／L]均显著降低（P均〈0．05）；斑块组的结合胆红素水平显著低于对照组[（4．95±0．17）、（5．70±0．28）μmol／L]。结论尿酸和胆红素在颈动脉斑块形成的不同阶段发挥不同的作用。
Objective To investigate the possible roles of serum bilirubin and uric acid in the course of carotid artery intima thicken/plaque formation. Methods Patients with ischemic cerebral vascular disease were divided into the control group,intima thicken group and plaque formation group according to the carotid artery intimamedia thickness （IMT） examination by B-mode ultrasound. The serum bilirubin and uric acid were detected by Automatic Chemistry Analyzer. Results The serum level of uric acid of （ 391.22 ± 27.52 ） μmol/L in intima thicken group was significantly higher than that in the control group and plaque formation group（ （307.32 ± 13.68 ） μmol/L and （ 327.84 ± 17.96 ） μmol/L, P 〈 0. 05 ）. The serum level of indirect bilirubin and total bilirubin in plaque formation group was （ 10. 96 ± 0. 58 ） μmol/L and （ 15.91 ± 0. 71 ） μmol/L respecitively, which were significantly lower than those in the control group （ （ 15.09 ± 2. 21 ） μmol/L and （ 20. 59 ± 2.43 ）μmol/L, respectively） and the intima thicken group（ （ 15.09 ± 2. 21 ）μmol/L and （20. 59 ± 2. 43 ）μmol/L, respectively） （P 〈 0. 05 ） . The serum level of direct bilirubin in the plaque formation group （ （ 4. 95 ± 0. 17 ） μmol/L ） was significantly lower than that of （ 5.70 ± 0. 28 ） μmol/L in the control group（ P 〈 0. 05 ）. Conclusions Bilirubin and uric acid play different roles in carotid artery plaque formation during different stage.
出处
《中国综合临床》
2010年第9期943-945,共3页
Clinical Medicine of China
关键词
颈动脉斑块
缺血性脑血管病
胆红素
尿酸
Carotid artery plaque
Ischemic cerebral vascular disease
Bilirubin
Uric acid
