摘要
目的观察连续性血液净化（CBP）治疗在重症急性胰腺炎（SAP）患者治疗中的作用。方法将26例SAP患者随机分为常规组和CBP组，常规组给予传统常规治疗，CBP组在常规治疗基础上，给予CBP治疗。观察2组患者治疗前及治疗后2、5d的APAtCHEⅡ评分、C-反应蛋白（CRP）；2组的机械通气时间、住ICU时间及病死率。结果常规组治疗2、5d后的APACHElI评分为：11．61±3．00、10．76±4．30，CRP为：（149．71±60．06）、（101．21±33．98）mg／L；CBP组才目应为：8．20±1．87、6．19±1．49，（109．17±23．91）、（70．83±25．45）mg／L，2组间差异有统计学意义（P均〈0．05）；常规组机械通气时间、住ICU时间、病死率为：（13．29±6．23）、（16．00±6，86）d，21．43％（3／14）；CBP组相应为（8．00±5．27）、（10．33±4．81）d。8．33％（1／12），2组间差异有统计学意义（P均〈0．05）。结论CBP可以有效改善SAP患者的APACHEⅡ评分，降低CRP，缩短机械通气时间及住ICU时间，降低病死率，应在临床工作中推广应用。
Objective To investigate the effect of continuous blood purification（CBP） in the patients with severe acute pancreatitis（SAP）. Methods Twenty-six patients with severe acute pancreatitis were divided into the control group and the observation group randomly. Fourteen cases in the control group were given conventional treatment only, 12 cases in CBP group were given continuous blood purification as well as the conventional treatment. The APACHE II score and CRP of pre- and intra-treatment at the 2nd and 5th day were observed in the two groups. The duration of mechanical ventilation, the duration of ICU stay, the mortality of hospital were observed as well. Results The APACHE II score and CRP of the second day and the fifth day of intra-treatment in the control group were 1.61 ± 3.00,10. 76 ± 4. 30, （ 149. 71 ± 60. 06 ） mg/L and （ 101.21± 33.98 ） mg/L, respectively, which were significantly different to those of （ 8.20±1.87 ） mg/L, （ 6. 19 ± 1.49 ） rag/L, （ 109. 17 ± 23.91 ） mg/L, （70. 83± 25.45 ）mg/L in the CBP group （P 〈 0. 05 ）. The duration of mechanical ventilation, the duration of ICU stay and the mortality of hospital were （ 13.29 ±6.23 ） d, （ 16. 00 ± 6. 86 ） d, 21.43% in the control group, which were significantly lower than those of （8.00± 5.27 ） d, （ 10. 33±4. 81 ） d, 8.33% in the other group （ P 〈 0. 05）. Conclusions CBP is an effective method for the patients with severe acute pancreatitis to shorten the duration of mechanical ventilation and the ICU stay, and decrease the mortality of hospital.
出处
《中国综合临床》
2010年第9期931-932,共2页
Clinical Medicine of China
关键词
连续性血液净化
重症急性胰腺炎
Continuous blood purification
Severe acute pancreatitis
