摘要
目的研究高渗高胶液体——高渗氯化钠羟乙基淀粉40(HH40)溶液对兔肺挫伤进行治疗的效果及可能的机制分析。方法新西兰白兔20只随机分为2组:实验(HH40)组和对照组。制作肺挫伤模型,60 min后分别应用HH40注射液和林格氏液进行输液治疗。在6 h后将动物处死,取右肺检测其干湿比,测定肺组织中髓过氧化物酶活性和细胞间粘附分子-1的表达,并观察肺组织病理结构的变化。结果实验组的干湿比和髓过氧化物酶也明显低于对照组(P<0.01),其肺组织中I细胞间粘附分子-1的表达也明显低于对照组(P<0.01),肺组织病理变化较对照组轻。结论高渗高胶液体对肺损伤有较好的治疗作用。
Objective To investigate the effects of hypertonic sodium chloride hydroxyethyl starch 40 （HH40） injection in pulmonary contusion rabbits. Methods Twenty rabbits were randomly divided into 2 groups ： the trail group （ HH40 group） and the control group. The animals were created the pulmonary contusion models. After 60 min, the animals in HH40 group received HH40 injection 5 ml/kg, and those in control group 5 ml/kg LRS. The animals were killed six hours later,the right lung tissue wet -to -dry （W/D） ratio and myeloperoxidase （MPO） activity were obtained, the protein expression of in- tercellular adhesion molecule - 1 （ ICAM - 1 ） were also detected. Results The lung tissue W/D, MPO, and the protein expression of ICAM -1 were decreased evidently in HH40 group （P 〈0.01 ）. The morphologic damages in HH40 group were milder than in control group. Conclusion HH40 injection is effective on pulmonary contusion rabbits.
出处
《中国医学创新》
CAS
2010年第22期19-20,共2页
Medical Innovation of China
关键词
高渗氯化钠羟乙基淀粉40
肺挫伤
细胞间粘附分子-1
Hypertonic sodium chloride hydr0xylethyl starch 40
Pulmonary contusion
Intercellular adhesion molecule - 1
