摘要
目的探讨阿立哌唑与氯氮平对首发精神分裂症患者心电图影响的差异。方法将100例首发精神分裂症患者随机分为两组,每组50例,分别给予阿立哌唑和氯氮平治疗。于治疗前和治疗后第2、4、8周定期进行心电图检查,并对结果进行对比分析。结果阿立哌唑和氯氮平对精神分裂症患者的心电图均有影响,但阿立哌唑组所致心电图改变发生率明显低于氯氮平组(P<0.01),异常程度轻,以ST-T改变和窦性心律失常为主。结论阿立哌唑可引起心电图发生改变,但发生率低,心电图改变程度轻,安全性相对较大。
Objective To study the effects of aripiprazole and Clozapine on ECG of the primary schizophrenia patients. Methods One hundred of primary schizophrenic patients were randomly divided into two groups with each group of fifty patients respectively treated with aripiprazole and elozapine All the patients were carried ECG before treatment then2,4 and 8 weeks laterAnd the results were processed by statistical methods. Results Both aripiprazole and clozapine had effects on ECG, but compared to the elozapine group, the aripiprasole group had less and smaller changes of ECG which was mainly nodal taehyeardia. Conclusion Compared to clozapine, aripiprazole had less and smaller effect on EKG of the primary schizophrenic patients and was much safer for treatment.
出处
《中国医学创新》
CAS
2010年第22期10-11,共2页
Medical Innovation of China
