摘要
目的研究凋亡抑制基因Survivin在乳腺癌组织中的表达及其临床意义。方法应用免疫组织化学SP法,检测Survivin在43例乳腺癌组织12例正常乳腺组织中的表达。结果乳腺癌组Survivin蛋白阳性表达率62.8%(27/43)显著高于正常组0%(0/12)(P<0.05);淋巴结转移组Survivin蛋白阳性表达率(75%,21/28)显著高于无淋巴转移组(46.2%,6/15)(P<0.05);根据临床病理分期,Ⅰ+Ⅱ期组与Ⅲ+Ⅳ期组之间Survivin蛋白阳性表达率(50.0%νs70.4%)差异有统计学意义(P<0.05);随临床分期增加、淋巴结的转移,Survivin蛋白阳性表达率逐渐升高(P<0.05)。结论 Survivin的异常表达与乳腺癌的发生、发展密切相关,其在乳腺癌中的高表达与淋巴结转移及临床病理分期密切相关,可能是影响乳腺癌预后的重要分子指标。
Objective Aim To investigate the expression of survivingene inbreast carcinoma andstudy its clinical significance.Methods The expression of survivin were detected by immunohistochemistry SP method in 43 cases of breast carcinoma,12 of adjacent normal breast tissue.Results 62.8 percent（27 of 43） of cases had expression of survivin in the tumor cells,and 0 percent（0 of 12） of cases of the normal tissue it were present.There was a significant positive correlation between breast carcinoma specimens and normal tissue specimens（P〈0.01）.Tumors with lymph node metastases（75.0%） had high survivin protein expression than those without metastasis（46.2%）（P〈0.05）.The survivin expression between Ⅰ＋Ⅱand Ⅲ＋Ⅳ stage,the difference was significant（50.0% νs70.4%）（P〈0.05）.Conclusion Survivin gene play an important role in the occurrence and development of breast carcinoma.It is suggested that survivin can be a useful marker for predicting invasion and metastasis ability of breast carcinoma.
出处
《中国现代药物应用》
2010年第18期1-2,共2页
Chinese Journal of Modern Drug Application
