摘要
目的观察幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，ＨＰ）感染与冠心病（ｃｏｒｏｎａｒｙｈｅａｒｔｄｉｓｅａｓｅ，ＣＨＤ）的关系及对脂质代谢、血清免疫学的影响，探讨可能的发病机制。方法应用ＥＬＩＳＡ法测定冠心病组（９４例）和对照组（４０例）血清ＨＰ抗体（ＨｐＩｇＧ），同时应用全自动生化仪测定血清ＴＣ、ＴＧ、ＡｐｏＡ、ＡｐｏＢ含量。应用测定蛋白分析仪，通过散射比浊法测定血清ＩｇＧ、ＩｇＡ、ＩｇＭ、Ｃ３、ＣＩＣ含量。结果冠心病组血清ＨＰＩｇＧ阳性率明显高于对照组（５３．１９％ｖｓ２７．５％，Ｐ＜０．０１），急性心肌梗塞（ａｃｕｔｅｍｙｏｃａｒｉｄａｌｉｎｆａｒｃｔｉｏｎ，ＡＭＩ）和不稳定型心绞痛（ｕｎｓｔａｂｌｅａｎｇｉｎａｐｅｃｔｏｒｉｓ，ＵＡＰ）患者血清ＨＰＩｇＧ阳性率高于其他类型冠心病患者（Ｐ＜０．０５），ＨＰ阳性冠心病患者血清ＴＧ含量高于ＨＰ阴性患者（Ｐ＜０．０５），冠心病组血清ＩｇＧ和ＣＩＣ含量高于对照组（Ｐ＜０．０１），多元回归分析显示ＨＰ感染与冠心病发病呈正相关（Ｐ＝０．０４７）。结论ＨＰ感染可作为冠心病的独立危险因素，有ＨＰ感染的冠心病患者易于发生急性心肌梗塞和不稳定型心绞痛，ＨＰ感染可能?
Aim \ To investigate the relation of
Helicobacter pylori(HP) infection and coronary heart disease (CHD) and the effects on lipid
metabolism and serum immunology.\ Methods \ HPIgG(ELISA) and IgG,IgA,IgM,C3,CIC, and
total cholesterol(TC),triglyceride(TG),apolipoprotein A(ApoA),apolipoprotein B(ApoB) were
measured in 90 cases of CHD,with 40 healthy subjects as controls.\ Results \ The rate of
seropositive for HPIgG in CHO patients is significantly higher than that of controls(5319% vs
275%,P<001). In the cases of acute myocardial infarction(AMI) and unstable angina
pectoris(UAP) the rate of seropositive for HPIgG is higher than that in the cases of other types of
CHD(P<005). For the cases of CHD,the level of serumTG in these of HP seropositivity is higher
than that of HP seronegativity(P<005).The level of serum IgG and CIC in the cases are much
higher than that in controls(P<001). Regression analysis indicates that the HP infection is
related positively to CHD(P=0047). No correlation between HP infection and other risk factors
was found.\ Conclusion \ HP infection may be associated with CHD. HP infection may act
through immunoreaction or changes in lipid metabolism contributing to the pathogenesis of
CHD.
出处
《高血压杂志》
CAS
CSCD
1999年第2期122-124,共3页
Chinese Journal of Hypertension
关键词
幽门螺杆菌
感染
病理
冠心病
Helicobacter pylori
\ infection
\ coronary heart disease
