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甲状腺肿瘤相关基因研究进展

Research on the changes of genes in thyroid tumor
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摘要 甲状腺肿瘤是临床常见疾病,其良、恶性诊断缺乏特异性标志物,该疾病的发生与多种基因事件相关,包括BRAF、Ret/PTC、Ras、erBb-2、p53、p16、PTEN、CK19和DDIT3、ARG92、ITM1、C1orf24等基因。不同基因型的改变与甲状腺肿瘤的病理类型存在一定相关性。 Thyroid tumor is a kind of common disease in clinic. There no specific marker for the diagnosis of the disease although it is correlative with many kinds of genes, such as BRAF, Ret/PTC, Ras, erBb - 2, p53, p16, PTEN, CK19, DDIT3, ARG92, ITMI, Cloorf24 and so on. The changes happened in the above genes are correlative with different pathological types of thyroid tumor.
作者 戚峰 陈曦 王涛 刘彤
机构地区 天津医科大学总医院
出处 《中国医学创新》 CAS 2010年第23期194-196,共3页 Medical Innovation of China
关键词 甲状腺肿瘤 基因 BRAF Ret/PTC Thyroid tumor Gene BRAF Ret/PTC
分类号 R736.1 [医药卫生—肿瘤]
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参考文献24

  • 1Shuntaro L,Mikiharu F,Yoshto U,et al.B-raf,a new member of the raf family,is activated by DNA rearrangment.Molecular Celluar Biology,1988,8(6):2651-2654.
  • 2Sapio MR,Posca D,Tronconel G,et al.Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification(MASA).Eur J Endocrinol,2006,154(2):341-348.
  • 3Costa AM,Herrero A,Fresno MF,et al.BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma.Clin Endocrinol (Oxf),2008,68(4):618-634.
  • 4Salvatore G,De Falco V,Salerno P,et al.BRAF is a therapeutic target in aggressive thyroid carcinoma.Clin Cancer Res,2006,12(5):1623-1629.
  • 5Chiloeches A,Marais R.Is BRAF the Achilles Heel of thyroid cancer? Clin Cancer Res,2006,12(6):1661-1664.
  • 6Castro P,Rebocho AP,Soares RJ,et al.PAX8-PPAR{gamma} rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.J Clin Endocrinol Metab,2005,90(12):6373-6379.
  • 7Kim KH,Sub KS,Kang DW,et al.Mutations of the BRAF gene in papillary thyroid carcinoma and in Hashimotos thyroiditis.Pathol Int,2005,55(9):540-545.
  • 8Kodama Y,Asai N,Kawai K,et al.The RET proto-oncogene:a molecular therapeutic target in thyroid cancer.Cancer Sci,2005,96(3):143-148.
  • 9Lee S,Hong SW,Moon WC,et al.High prevalence of c-RET expression in papillary thyroid carcinomas from the Korean population.Thyroid,2005,15(3):259-266.
  • 10Penko K,Livezey J,Fenton C,et al.BRAF mutations are uncommon in papillary thyroid cancer of young patients.Thyroid,2005,15(4):320-325.
中国医学创新
2010年 第23期

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