摘要
检测５２例非胰岛素依赖性糖尿病（ＮＩＤＤＭ）患者尿Ｎ乙酰βＤ氨基葡萄糖苷酶（ＮＡＧ）活性和尿微量白蛋白（ｍＡＬＢ），结果显示：ＮＩＤＤＭ患者尿ＮＡＧ活性显著高于对照组（Ｐ＜０．００１），与尿ｍＡＬＢ呈显著正相关。尿ＮＡＧ和ｍＡＬＢ增高百分率分别为５７．７％和５９．６％，两者差异无显著性（Ｐ＞０．０５），提示尿ＮＡＧ诊断早期糖尿病肾病（ＤＮ）的敏感性与ｍＡＬＢ相仿。同时监测糖尿病患者尿ＮＡＧ和ｍＡＬＢ，有助于提高早期糖尿病肾病诊断的准确率。
Urinary N acetyl β D glucosaminidase(NAG) activity and microalbumin(mALB) were determined in 52 patients with non insulin dependent diabetes mellitus(NIDDM).The results showed that NAG activity increased remarkably in NIDDM than in the control and had a significant correlation with mALB.The percentage of increased value of NAG and mALB were 57.7% and 59.6% respectively.Between them there was no significant difference(P>0.05),which suggested that NAG was similar to mALB in sensitivity for diagnosing diabetic nephropathy at its early stage.It seams that assaying urincary NAG and mALB is the best way for screening of early renal involvement in diabetes.
基金
衡阳市科委资助
关键词
糖尿病肾病
微量白蛋白
尿
NAG
诊断
diabetic nephropathy
N acetyl β D glucosaminidase
microablbumin
Urine
