摘要
目的探讨外源性铜蓝蛋白(CP)对脑出血后脑水肿的可能作用。方法建立大鼠脑出血模型,分为脑出血组和CP处理组,检测脑组织水含量及脑Na+含量的差异,观察实验动物的神经功能恢复情况。结果脑出血后3d及7d,CP处理组脑组织水含量明显降低,基底节脑组织Na+含量降少,差异均有统计意义(t分别=2.13、2.56、4.57、3.51,P均<0.05);脑出血3d后,CP处理组神经功能恢复也较脑出血组明显改善,尤在3d、21d及30d观察点显示,CP处理组转角试验结果低于脑出血组,CP处理组前置放置试验高于脑出血组,差异均有统计学意义(t分别=1.82、1.79、2.03;2.16、2.03、3.03,P均<0.05)。结论 CP可能在脑出血后脑水肿的发生发展中起重要作用。
Objective To examine whether exogenous ceruloplasmin reduces brain edema induced after intracerebral hemorrhage （ICH）. Methods Male Sprague-Dawley rats received an infusion of 100 μl autologous blood or 100 μl autologous blood plus 5 μM ceruloplasmin into the right basal ganglia. The brain water and ion content in rat brain were measured 3 days,7 days after ICH. Behavioral tests （corner turn test, forelimb placing test） were used to examine neurological deficits. Results After intracerebral hemorrhage and 7 days, 3 days with CP, water content, Na＋ content of the brain tissue of basal ganglia reduced with statistical significance（t=2.13,2.56,4.57, 3.51, P0.05）. After hemorrhage and 3 days with CP, neurological recovery was obviously improved. Especially in 3 days, 21 days and 30 days, the results of corner test and forelimb placing test had significant differences between the hemorrhage group and CP group（t=1.82,1.79,2.03,2.16,2.03,3.03, P0.05）. Conclusions Ceruloplasmin may be an important point in brain edema formation after ICH.
出处
《全科医学临床与教育》
2010年第4期402-404,共3页
Clinical Education of General Practice
基金
浙江省医药卫生科学研究基金(2007A116)
浙江省中医药科技计划(2008CA061)
关键词
脑出血
脑水肿
铜蓝蛋白
铁
intracerebral hemorrhage
brain edema
ceruloplasmin
iron
