摘要
目的探讨促性腺激素释放激素激动剂（GnRH-a）治疗卵巢子宫内膜异位囊肿的临床疗效与不良反应。方法 98例卵巢子宫内膜异位囊肿患者随机分为单纯手术组（A组）40例,联合治疗组58例,观察两组治疗后疗效和不良反应等。结果 A组随访的34例中,15例有效,有效率为44.12%,5例症状改善,改善率14.71%,14例术后5个月再次发现盆腔包块,复发率41.18%;B组随访的49例中,40例有效,有效率为81.36%;9例停药后8个月再次出现盆腔包块,但较术前直径小,复发率18.37%。结论手术联合GnRH-a治疗子宫内膜异位症安全、有效,但可发生潮热、出汗、不规则阴道出血等低雌激素症状。
Aim To evaluate the efficacy and safety of the gonadotropin-releasing hormone agonist（GnRH-a） treatment of endometrio-sis.Methods The clinical symptoms and signs change and GnRH-a side effects were compared between surgical treatment group（A group） and surgery combined with GnRH-a treatment group（B） after treatment.Results 15 cases were effective（the effective rate was 44.12%）,5 cases were symptomatic improvement（the improvement rate was 14.71%）,14 cases were found pelvic mass again after 5 months（the recurrence rate was 41.18%） of all the 34 patients in A group;40 cases were effective（the effective rate was 81.36%）,9 cases were found pelvic mass again after 8 months（the recurrence rate of 18.37%）,but the mass was smaller than the preoperative di-ameter of all the 49 cases in B group.Conclusion Surgery combined GnRH-a treatment of endometriosis is safe and effective,but can occur hot flashes,sweating,irregular vaginal bleeding and other symptoms of low estrogen.
出处
《安徽医药》
CAS
2010年第10期1215-1216,共2页
Anhui Medical and Pharmaceutical Journal
