摘要
目的：进一步加深对于伴骨髓纤维化的骨髓增生异常综合征（ＭＤＳ－ＭＦ）这一特殊亚型的认识。方法：从临床、病理形态角度总结１２ 例ＭＤＳ－ＭＦ患者的特征。结果：所有病例均具备全血细胞减少、病态造血、骨髓纤维组织增生及预后较差的特征。该型不同于无骨髓纤维化的ＭＤＳ和原发性骨髓纤维化（ＩＭＦ），与前者的区别在于巨核细胞增多。对常规治疗反应不良，生存期明显缩短；与后者的区别在于无显著的肝脾肿大，骨髓较易抽取，有三系病态造血等。结论：ＭＤＳ－ＭＦ是一具有特色的亚型，有必要与ＩＭＦ和ＭＤＳ的其他亚型相区别。
Objective:To further define the myelodysplastic syndrome associated with myelofibrosis (MDS MF). Methods:Based on the clinical feature, cell/tissue morphology, twelve cases with MDS MF were retrospectively analyzed. Results:All of these patients had similar clinical and pathological features consisting of pancytopenia, trillineage dysplasia, marked reticulin fibrosis and poor survival. Conclusion:MDS MF may be a distinct clinic pathological entity which needs to be distinguished from other MDS subtype as well as from idiopathic myelofibrosis.
出处
《临床血液学杂志》
CAS
1999年第3期102-104,共3页
Journal of Clinical Hematology
关键词
骨髓增生异常综合征
骨髓纤维化
骨髓活检
预后
分类
Myelodysplastic syndrome Myelofibrosis Bone marrow biopsy Prognosis classification
