摘要
醋炔诺酮丙酰肟在大鼠和小鼠妊娠1～5天口服的抗着床ED_(50)分别为0.068±0.02和0.31±0.1mg/kg,大鼠妊娠第2天单次肌注或口服的抗着床ED_(50)分别为0.53±0.1和3.5±0.7mg/kg。大鼠妊娠7～8天肌注5～10mg/kg醋炔诺酮丙酰肟有明显的终止早孕作用。醋炔诺酮丙酰肟在终止早孕剂量时,明显抑制假孕大鼠的蜕膜反应且使早孕大鼠的血清孕酮浓度明显下降。提示:醋炔诺酮丙酰肟的终止早孕作用可能与其抑制孕激素活性有关。
Norethisterone acetate-3-proplonyloxyimino (NAP) was significantly effective for
anti-implantation and early pregnancy termination in both gravid rats and mice. The anti-
implantation ED_(50) by gavage from day 1-5 of gravidity in rats and mice were 0.068±0.02
and 0.31 ± 0.1 mg/kg respectively, and 0.53 ± 0.1 and 3.5 ± 0.7 mg/kg respectively in
rats by intramuscular injection and gavage on day 2 of gravidity. The early pregnancy
termination doses in rats were 5 and 10 mg/kg by intramuscular injection on day 7～8 of
gravidity. A dose of NAP sufficient to terminate the early pregnancy obviously inhibited the
decidua reaction in pseudopregnant rats and reduced the serum progesterone concentration
of early pregnant rats quite markedly. The early pregnancy termination action of NAP
might be related to its anti-progesterone activity.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1990年第4期41-46,共6页
Reproduction and Contraception
关键词
醋炔诺酮肟
炔诺酮肟
抗早孕
Norethisterone Acetate-3-Propionyloxyimino
Anti-implantation
Early pregnancy tormination
