摘要
目的：探讨前列环素（ＰＧＩ２）、血栓素Ａ２（ＴＸＡ２）在急性坏死性胰腺炎并发肾损害发病机制中的作用。方法：采用胰胆管结扎、胰腺被膜下注射５％牛磺胆酸钠复制急性坏死性胰腺炎肾损害大鼠模型，以放射免疫方法动态测定术后２４、４８小时肾静脉血浆和肾组织中血栓素Ｂ２（ＴＸＢ２）、ＰＧＩ２水平，并观察尿素氮（ＢＵＮ）、血肌酐（ＳＣｒ）的改变。结果：随着急性坏死性胰腺炎病程进展，肾静脉血浆和肾组织中ＴＸＢ２、６酮前列腺素１α（６ｋｅｔｏＰＧＦ１α）水平逐渐升高，ＴＸＢ２水平升高较６ｋｅｔｏＰＧＦ１α为甚，ＴＸＢ２／６ｋｅｔｏＰＧＦ１α比值增大，ＢＵＮ、Ｃｒ亦显著提高。结论：ＴＸＡ２和ＰＧＩ２平衡紊乱是急性坏死性胰腺炎并发肾损害的主要因素之一。
Objective:To assess the potential role of prostaglandin(PGI 2) and thromboxane(TXA 2) in the development of renal injury associated with acute necrotizing pancreatitis.Methods:A rat model of acute necrotizing pancreatitis with renal failure was produced by ligating bilepancreatic duct and injecting 5% sodium taurocholate under the pancreatic membranous layer.Changes in TXA 2 and PGI 2 levels in plasma and renal tissue were measured by radioimmunoassay at 24 and 48 hours after operation.The plasma blood urea nitrogen(BUN) and serum creatinine (SCr) contents were also determined.Results:The results showed that both plasma and tissue contents of thromboxane B 2(TXB 2) and 6ketoprostaglandin F 1α (6ketoPGF 1α ) gradually elevated,together with increase in TXB 2 to 6ketoPGF 1α ratio after acute necrotizing pancreatitis.Meanwhile,plasma BUN and SCr contents were significantly increased.Conclusions:These data suggest that imbalance of TXB 2 to 6ketoPGF 1α may be one of major factors responsible for renal failure induced by acute necrotizing pancreatitis.
出处
《中国危重病急救医学》
CSCD
1999年第5期270-272,共3页
Chinese Critical Care Medicine
关键词
胰腺炎
肾脏损害
前列环素
血栓素A2
acute pancreatitis
renal injury
prostaglandins
thromboxane A 2
