摘要
本文采用ELISA间接法对30对不明原因的不育夫妇血清及生殖道分泌液中ASA的阳性率、种类(IgG、IgM、IgA)及分布情况进行了研究。男性病人组血清中ASA阳性率为13.3%,精浆中为16.7%,和对照组相比无统计学意义。女性病人组血清中ASA阳性率为23.3%,宫颈粘液中为33.3%,和对照组相比均有显著差异。在不明原因的不育夫妇中,ASA主要发生在女方。检测结果表明,血清、精浆和宫颈粘液中均存在有IgG、IgM、IgA类ASA。但血清中主要为IgG、IgM类ASA,精浆及宫颈粘液中主要为IgA、IgG类ASA。ASA可同时存在于血清或生殖道分泌液中,也可单独存在于血清或生殖道分泌液中。
The occurrence and distribution of antisperm antibodies in the serum and/or genitaltract secretions as well as their class specificity of 30 unexplained infertile couples weredetermined by enzyme-linked immunosorbent assay (ELISA). In the male partners, inciden-ce of positive reaction in the serum accounted for 13.3%, while in seminal plasme,16.7%. There was no marked difference in the incidence of positive reaction of antibodiesbetween the control group and the infertile group. In the female partners, incidence of posi-tive reaction in the serum accounted for 23.3%, while in cervical mucus, 33.3%. Therewas statistically high significance between the infertile females and normal females. ASAmainly occurred in females. Subtypes IgG, IgM or IgA against spermatozoa were simulta-neously present in serum, Seminal plasma and cervical mucus of unexplained infertile cou-ples. IgG, IgM accounted for majority of antibody species in serum, while IgA, IgG werethe prevalent antibody species in seminal plasma and cervical mucus. Antisperm antibodiesmostly occurred in both serum and genital tract secretions, but sometimes in serum orgenital tract secretions only.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1990年第3期20-24,共5页
Reproduction and Contraception
关键词
抗精子抗体
不育症
ELISA
ELISA
Antisperm antibodies
Unexplained infertiiity
