摘要
目的 探讨和分析血清高敏C-反应蛋白（hs-CRP）及颈动脉粥样硬化与急性脑梗死的关系.方法 选取59例急性脑梗死患者为脑梗死组,同期选择健康体检者30例为对照组,测定血清hs-CRP含量,应用颈动脉彩色多普勒超声检查颈动脉粥样硬化斑块及颈动脉内膜-中膜厚度（IMT）.同时对急性脑梗死患者血清hs-CRP水平与病情进行相关分析.结果 血清hs-CRP脑梗死组为（5.96±1.52）mg/L高于对照组的（1.78±1.02）mg/L（t=15.383,P＜0.01）;颈动脉斑块检出率急性脑梗死组为77.97%,高于对照组的36.67%（x2=12.92,P＜0.01）;颈动脉IMT脑梗死组（1.18±0.17）mm高于对照组的（1.02±0.15）mm（t=4.544,P＜0.05）;神经功能缺损程度重型组血清hs-CRP水平[（15.68±1.45）mg/L]明显高于轻型组[（1.88±0.34）mg/L]和中型组[（4.16±1.39）mg/L]（t值为37.217和25.243,P＜0.01）.结论 血清hs-CRP水平升高对急性动脉粥样硬化性脑梗死病变有临床意义,早期测定hs-CRP水平有助于评估急性脑梗死患者的病情及预后.
Objective To investigate and analyze the relationship of the level of high-sensitivity C-reactive protein （hs-CRP） and carotid artery atherosclerosis with acute cerebral infarction （ACI）.Methods Fifty-nine patients with ACI were assigned as experimental group and thirty healthy people as control group. The serum level of hs-CRP was measured, and the carotid plaques and the changes of carotid intimal-medial thickness （IMT） were examined by color Doppler ultrasonography.Then the relationship between the serum level of hs-CRP and the severity of disease was analyzed.Results The serum level of hs-CRP was higher in ACI group than in control group [（5.96± 1.52）mg/L vs. （1.78±1.02） mg/L, t=15.383, P〈0.01]. The detection rates of carotid plaques and the increased carotid IMT were higher in ACI group than in control group [77.97% vs. 36.67%, x2 =12.92, P〈0.01; （1.18±0.17） mm vs. （1.02±0.15） mm, t=4.544, P〈0.05]. The hs-CRP levels were higher in the severe cases [（15.68±1.45） mg/L] than in moderate cases [（4.16±1.39）mg/L] and mild cases [（1.88±0.34） mg/L, t=37. 217, 25. 243, both P〈0.01]. Conclusions The elevated levels of hs-CRP have overt clinical significances for the atherothrombotic cerebral infarction. Early determination of hs-CRP is helpful to evaluate patient＇s condition and prognosis.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2010年第8期629-631,共3页
Chinese Journal of Geriatrics
关键词
脑血管意外
C反应蛋白质
颈动脉疾病
Cerebrovascular accident
C-reactive protein
Carotid artery diseases
