摘要
目的:观察碱性成纤维细胞生长因子(bFGF)对慢性酒精中毒大鼠血清GPT、GOT活性的影响,探讨bFGF对酒精中毒所致的肝损伤是否具有保护作用。方法:选择成年Wistar雄性大鼠,采用白酒灌胃建立慢性酒精中毒模型,慢性酒精中毒模型建立成功的大鼠采用随机抽签法分为酒精中毒对照组、NS对照组和bFGF治疗组。另10只不灌白酒作为正常对照组。bFGF治疗组大鼠白酒灌胃的同时,1h后按12μg/kg剂量肌内注射,共14d。各组大鼠到相对应的时间点取血测定血清谷丙转氨酶(GPT)、谷草转氨酶(GOT)活性。结果:慢性酒精中毒后大鼠血清GPT、GOT活性比正常对照组均明显升高(P<0.01),用bFGF治疗酒精中毒大鼠后血清GPT、GOT活性均明显下降(P<0.01)。结论:bFGF能降低酒精中毒大鼠后血清GPT和GOT活性,对酒精中毒所致的肝损伤具有保护作用。
Objective：To study the effects of basic fibroblast growth factor （bFGF）on the activities of GPT and GOT in serum of rat model of alcoholism. Methods：The rat model of alcoholism were established by perfusing stomach with alcohol 40 Wistar rats were randomly divided into of model of control group,model of alcoholism group,normal saline （NS） and bFGF treatment group.The activities of Glutamic pyruvic transaminase （GPT） and Glutamic oxaloacetic transaminase （GOT） in serum were detected. Results：The activities of GPT and GOT in serum were significantly increased than those in control group （P0.01）.After bFGF treatment, the activities of GPT and GOT in serum of the bFGF group were significantly decreased compared with the NS control group and model of alcoholism group respectively （P0.01）.Conclusion：bFGF can decrease the activities of GPT and GOT in serum in alcohol induced alcoholism model rats.
出处
《中国当代医药》
2010年第27期7-8,共2页
China Modern Medicine
基金
广西教育厅科研项目(200810LX045)
关键词
碱性成纤维细胞生长因子
酒精中毒
肝损伤
谷丙转氨酶
谷草转氨酶
Basic fibroblast growth factor
Chronic alcoholism
Liver damage
Glutamic pyruvic transaminase
Glutamic oxaloacetic transaminase
