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CD36与动脉粥样硬化 被引量：13

CD36 and Atherosclerosis
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摘要 CD36是在多种组织细胞上表达的跨膜糖蛋白,属于B族清道夫受体。单核巨噬细胞上的CD36是吞噬摄取氧化型低密度脂蛋白的主要受体。除介导泡沫细胞形成外,CD36还有促进凝血和单核细胞聚集,促进炎症反应和氧化、凋亡等多种功能,其表达可被高度调控,是巨噬细胞泡沫化和动脉粥样硬化发生发展的重要因素。 CD36, belongs to class B scavenger receptor family, is a transmembrane glycoprotein expressed on various tissues. On macrophages, CD36 is a major scavenger receptor for oxidized low density lipoprotein（ ox-LDL）. In addition to its significant roles in atherosclerosis, CD36 also exerts multiple roles including promoting coagulation and monocytes accumulation, pro-inflammatory and antioxidant roles, etc. The expression of CD36 is highly regulated by many factors, and plays an important role in the development of atherosclerosis.
作者 靳文英(综述 陈红(审校)
机构地区 北京大学人民医院心脏中心
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2010年第7期582-585,共4页 Chinese Journal of Arteriosclerosis
关键词 CD36 动脉粥样硬化 清道夫受体 CD36 Atherosclerosis Scavenger Receptor
分类号 R363 [医药卫生—病理学]
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参考文献31

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二级参考文献15

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二级引证文献85

中国动脉硬化杂志
2010年 第7期

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