摘要
目的观察玻璃体腔内注射曲安奈德(TA)后眼压的早期变化以及前房穿刺对眼压的影响。方法将接受玻璃体腔内注射TA治疗的20例20眼患者随机分为前房穿刺组(A组)和未进行前房穿刺组(B组),各10例10眼。A组在玻璃体腔内注射TA后前房穿刺并抽取0.05 mL房水,B组仅玻璃体腔内注射TA。应用Goldmann眼压计于玻璃体腔内注射前及注射后2、15、30 min,1 h,1 d,1周测量眼压,对2组注射前后眼压的变化进行对比研究。结果 A组注射前平均眼压为(13.70±2.52)mmHg,注射后2 min时为(8.20±1.33)mmHg,15 min时为(11.32±1.52)mmHg,A组注射后2 min时的眼压明显低于组内其他时间点,差异均有统计学意义(P<0.01)。B组注射前平均眼压为(15.32±1.73)mmHg,注射后2 min时为(39.23±9.31)mmHg,15 min时为(16.24±3.52)mmHg,B组TA注射后2 min眼压明显高于注射前,差异有统计学意义(P<0.01),注射后15 min恢复到正常眼压水平(16.24±3.52)mmHg。A组在注射后2 min的眼压明显低于B组同时间点的眼压,差异有统计学意义(P<0.01)。A组注射后早期可见一过性前房闪辉,B组未见眼部不良反应。结论玻璃体腔内注射TA后早期可引起一过性眼压升高,可选择性进行前房穿刺。前房穿刺和玻璃体腔内TA注射是安全的。
Background Triamcinolone acetonide（TA）has been topically used in the treatment of various intraocular diseases,but its complication and adverse effect on ocular tissue are noticeable.ObjectiveThis trial was designed to investigate the early intraocular pressure（IOP）change and efficacy of anterior chamber paracentesis after intravitreal injection of（TA）.MethodsA prospective,randomized-controlled clinical trial was conducted on 20 eyes of 20 patients underwent intravitreal injection of TA.The patients were randomly divided into paracentesis＋TA injection group and only TA injection group according to with or without anterior chamber paracentesis and aspiration of 0.05 ml aqueous humour after intravitreal injection of TA.IOP was measured before injection and 2,15,30 minutes,1 hour,1 day and 1 week after injection with Goldmann tonometer.Written informed consent was obtained from each patient prior to the intravitreous injection.ResultsIn paracentesis＋TA injection group,the mean preoperative IOP was（13.70±2.52）mmHg,and in postoperation,the IOP was（8.20±1.33）mmHg at 2 minutes and（11.32±1.52）mmHg at 15 minutes.In only TA injection group,the IOP was significantly elevated at 2 minutes after injection（39.23±9.31mmHg）in comparison with paracentesis＋TA injection group（P0.01）,and then the IOP declined to normal within 15 minutes（16.24±3.52mmHg）.The IOP was lowest at 2 minutes after paracentesis and TA injection in paracentesis＋TA injection group and highest at 2 minutes after TA injection in only TA injection group,showing significant differences in comparison with other time points（P0.01）.Temporary anterior chamber opacity was found at the early stage in paracentesis＋TA injection group and no any adverse response was seen in only TA injection group.ConclusionInjection of TA into the anterior chamber results in temporary enhance of IOP.Anterior chamber paracentesis may be selectely applied to reduce the IOP after TA injection.Anterior chamber paracentesis and intravitreal injection of TA is safe.
出处
《眼科研究》
CAS
CSCD
北大核心
2010年第9期892-895,共4页
Chinese Ophthalmic Research
关键词
眼压
玻璃体腔内注射
前房穿刺
曲安奈德
intraocular pressure
intravitreal injection
anterior chamber paracentesis
triamcinolone acetonide
