摘要
目的探讨戊型肝炎(戊肝)合并肝内胆汁淤积的临床特点。方法对106例胆汁淤积型戊肝的临床特点及治疗进行回顾性分析。结果 106例胆汁淤积型戊肝中,59例为单纯戊肝(其中28例有长期大量饮酒史),16例为乙、戊型肝炎病毒重叠感染,3例为丙、戊型肝炎病毒重叠感染。6例发展为重型肝炎,其中3例合并乙型肝炎,2例有长期饮酒史,1例为单纯性戊肝。经保肝、退黄等综合治疗,总治愈例数102例,3例发展为坏死后肝硬化(均为重型肝炎),1例临床死亡。结论戊肝患者起病急,重症较多,易合并肝内胆汁淤积。经积极综合治疗(包括肾上腺皮质激素治疗及人工肝支持系统治疗),预后良好,但病程长,部分患者因胆汁淤积时间长可能出现胆汁淤积性肝硬化。
Objective To investigate the clinical features of hepatitis E combined with cholestasis. Method Clinical features and treatment of 106 patients with hepatitis E combined with cholestasis were analyzed retrospectively. Results Of the 106 patients, 59 were infected with hepatitis E virus only, of whom 28 had long-term heavy alcohol use, 16 had the superinfection with hepatitis B virus, and 3 had the supefinfeetion with heptitls C virus. Six patients progressed to severe hepatitis, of whom 3 had the superirffection with hepatitis B virus, 2 had long-term alcohol use, and 1 had hepatits E only. Comprehensive treatment such as li- ver-protecting and jaundice-abating treatment was given. Totally 102 patients were cured, 3 progressed to postnecrotic cirrhosis and 1 died. Conclusions Patients with hepatitis E may have rapid onset, and hepatits E is likely to develop severe conditions and liable to he combined with cholestasis. After active comprehensive treatment, including glucocorticoid treatment and artificial liver support therapy, prognosis is good, but the course of the disease is long, and some of the patients may develop cholestatic liver cirrhosis due to long-term cholestasis.
出处
《传染病信息》
2010年第4期242-244,共3页
Infectious Disease Information
