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造血干细胞移植后嵌合体的检测方法及临床意义

Detection methods and clinical significance of chimerism after hematopoieticstem cell transplation
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摘要 造血干细胞移植后动态监测供受者嵌合状态，对于疾病转归、提高移植成功率，减少疾病复发等方面有重要意义，应用不同分子遗传学标记结合定量PCR检测嵌合体，尤其是对系列特异细胞嵌合体进行动态定量分析研究，对临床治疗具有重要的指导价值。 Sequential monitoring of chimerism after hematopoietic stem cell transplantation is important for disease prognosis, improving transplantation success rate, and reducing relapses of the original diseases. The application of molecular genetic markers in combination with quantitative PCR to the assessment of chimerism, in particularly the dynamic quantitative analysis of lineage-specific chimerism, can provide important guidance for clinical practice.
作者 段静静(综述) 苏丽萍(综述)
机构地区 山西医科大学研究生院 山西省肿瘤医院血液科
出处 《国际肿瘤学杂志》 CAS 2010年第8期626-629,共4页 Journal of International Oncology
关键词 造血干细胞移植 嵌合体 聚合酶链反应 Hematopoietic stem cell transplation Chimera Polymerase chain reaction
分类号 R512.62 [医药卫生—内科学]
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参考文献18

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二级参考文献34

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国际肿瘤学杂志
2010年 第8期

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