摘要
1例18岁男性患者因急性T淋巴细胞白血病行造血干细胞移植。移植第22天静脉滴注环孢素25mg,2次/d,5d后改为35mg,2次/d,并给予膦甲酸钠3g/12h静脉滴注。用药第20天,患者出现恶心、呕吐,随即出现双眼凝视、呼之不应,伴有四肢抽搐、意识丧失,同时血清肌酐升高至129μmol/L。给予苯巴比妥镇静、甘露醇脱水等对症治疗。停用膦甲酸钠,环孢素减为25mg,1次/12h后患者未再有症状性癫痫发作,肌酐水平也逐渐降至正常。
A 18-year-old man underwent hematopoietic stem cell transplantation for acute T lymphoblastic leukemia. On day 22 transplantation,the patient received an IV infusion of cyclosporine 25 mg twice daily and,5 days later,the dose was increased to 35 mg twice daily,and meanwhile an infusion of foscarnet sodium 3 g twice daily was given. On day 20 of therapy,the patient developed nausea,vomiting,gaze in both eyes,and no response to voice stimuli accompanied by convulsions in limbs and loss of consciousness. His serum creatinin level increased to 129 μmol/L. Phenobarbital used for sedation,mannitol used for dehydration,and other symptomatic treatments were given. After foscarnet sodium was discontinued and cyclosporine dose was decreased to 25 mg every 12 hours,his epileptic seizures did not recur and the serum creatinine level returned to within normal range.
出处
《药物不良反应杂志》
2010年第4期239-239,245,共2页
Adverse Drug Reactions Journal
关键词
膦甲酸钠
不良反应
癫痫发作
肾损害
foscarnet sodium
adverse drug reactions
epileptic seizures
renal damage
