摘要
目的:观察心宁片对麻醉开胸犬心脏血流动力学及心肌耗氧量的影响,研究其对心脏功能的药理作用及机制。方法:观察心宁片对正常麻醉开胸犬冠脉动脉血流量、心输出量、心肌耗氧量等指标的影响。结果:心宁片可扩张冠脉血管及外周血管,增加冠脉流量,降低冠脉阻力,增加心肌供血能力;改善左室作功,调整心脏血管的顺应性,对心脏具有正性调节作用;同时可增加心输出量和心搏出量,降低外周阻力;明显增加冠状静脉窦血氧含量,降低心肌耗氧指数和心肌氧利用率。结论:心宁片具有调整和改善心血管系统的作用。
Objective： To observe the pharmacological effects of Heart tablets on cardiac function and its mechanism,the effects on cardiac hemodynamics and myocardial oxygen consumption in anesthetized dogs were observed.Method： Observe the effect of Heart tablets on coronary blood flow,cardiac output,myocardial oxygen consumption and other indicators in normal anesthetized dogs.Result： The Heart tablets can increase femoral arterial blood pressure,while no effect is found on the heart rate,standard Ⅱ ECG PR interval,QRS interval,QT interval,T wave and other parameters.The tablets can expand coronary artery and peripheral vessel,increase coronary blood flow,lower coronary resistance and increase cardiac blood supply capacity,improve left ventricular function,ameliorate cardiovascular adaptability,increase dp/dtmax,enhance myocardial activity and have a positive regulatory role in heart.At the meantime raise the cardiac output and stroke volume were raised,so that blood pressure can be increased,while the total peripheral resistance was decreased.The coronary vein sinus oxygen content were significantly increased and myocardial oxygen consumption index and myocardial oxygen utilization were reduced.Conclusion： The tablets can adjust and improve the cardiovascular system.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第18期2480-2487,共8页
China Journal of Chinese Materia Medica
基金
湖南省科技厅重点项目(05SK2007)
关键词
心宁片
血流动力学
冠脉血流量
心输出量
心肌耗氧量
Heart tablets
myocardial oxygen consumption
coronary blood flow
cardiac output
myocardial oxygen consumption
