摘要
目的：观察动物对茶多酚的急性和慢性的毒性反应。方法：小鼠分５组，剂量比值为１∶０．８，连续灌胃７ｄ。按Ｂｌｉｓ法计算茶多酚ＬＤ５０。大鼠分对照组，茶多酚高、中、低剂量组（０．４ｇ／ｋｇ·ｄ－１、０．６ｇ／ｋｇ·ｄ－１和０．８ｇ／ｋｇ·ｄ－１），连续灌胃９０ｄ。结果：茶多酚ＬＤ５０为２．４９９ｇ／ｋｇ。动物长期服用茶多酚未出现体重、血常规、肝肾功能及脏器组织的毒性变化。结论：茶多酚属低毒性，对大鼠０．８ｇ／ｋｇ·ｄ－１的剂量相当于成人用量的１００倍以上。
Objective:The study was to observe the acute and chronic toxicity of Tea Polyphenols(TP).Methods:the mice were divided into five groups and TP was given orally for 7 days.The method of Bliss was used to determine the LD 50 of the TP.The rats was divided into control group,TP high dosage group,TP middle dosage group and low dosage group(0.4,0.6,0.8g/kg·d -1 ) to observe the chronic toxicity.Result:The LD 50 of TP is 2.499g/kg.The rats have showed no toxicity reaction in weight,blood,the internal organs,liver and kidneys function after the using of the drug.Conclusion:The TP has low toxicity,the dosage of 0.8g/kg.d -1 in rat is equivalent to 100 times of the dosage used in clinic for an adult.It indicates that the clinical using of TP is safe.
出处
《安徽中医学院学报》
CAS
1999年第2期37-39,共3页
Journal of Anhui Traditional Chinese Medical College
基金
安徽省自然科学基金
关键词
茶多酚
毒性实验
慢性
Tea polyphenols
Acute toxicity test
Chronic toxicity test
