摘要
本文用微电极细胞内电位记录、通道阻断剂和放射性同位素等技术发现,锌离子可诱发爆发波放电(BD),钠通道阻断剂——河豚毒素对BD无效应,而钙通道阻断剂——Ca^(2+)则可使BD消失,Cd^(2+)可使[^(65)Zn^(2+)];量减少。以上结果说明,Zn^(2+)诱发BD的产生机理很可能是Zn^(2+)代替Ca^(2+)通过钙通道进入胞内引起的。
The intracellular microelectrode recording technique, channel blocker and radioisotope tracer method were used. The burst discharges were evoked by Zn^(2+), no change by sodium channel blocker——Tetrodotoxin, but abolished by calcium channel blocker——Cd^(2+). [^(65)Zn^(2+)]; was decreased by Cd^(2+). It is possible, that Zn^(2+), instead of Ca^(2+), goes into cells through calcium channels in the mechanism of BD evoked by Zn^(2+).
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1990年第2期117-120,共4页
Progress In Biochemistry and Biophysics
