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木犀草素镇痛抗炎作用的实验研究 被引量：21

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摘要 目的研究木犀草素的镇痛、抗炎作用。方法以乙酰水杨酸为阳性对照,采用小鼠热板法和化学刺激法观察木犀草素的镇痛作用,采用二甲苯致小鼠耳廓肿胀法和角叉菜致大鼠足跖肿胀模型观察木犀草素的抗炎作用。结果木犀草素(1mg·kg-1.d-1,ig)能明显延长小鼠对热刺激疼痛反应的潜伏期(痛阈值),使小鼠扭体反应的发生率降低,10min和20min扭体反应抑制率分别为30%和25%,并使小鼠10min、20min内扭体次数明显减少,与生理盐水组比较有显著性差异(P<0.05)。木犀草素能明显减轻二甲苯所致的小鼠耳廓肿胀和角叉菜所致的大鼠足肿胀,与生理盐水组比较差异显著(P<0.05)。木犀草素的镇痛及抗炎作用强度与乙酰水杨酸(0.2g·kg-1.d-1,ig)相近。结论木犀草素具有明显的镇痛抗炎作用。
作者 刘圆 李园园 冯婷婷 胡金民 马霖 王丽娟
机构地区 天津商业大学生物技术与食品科学学院制药系
出处 《齐齐哈尔医学院学报》 2010年第15期2368-2370,共3页 Journal of Qiqihar Medical University
基金 天津商业大学大学生科研训练课题资助
关键词 木犀草素 镇痛作用 抗炎作用
分类号 R285.5 [医药卫生—中药学]
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参考文献8

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二级参考文献16

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共引文献63

同被引文献278

引证文献21

二级引证文献142

齐齐哈尔医学院学报
2010年 第15期

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